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基于四苯基卟啉锰与碳纳米线圈界面的酪氨酸电化学传感

Manganese tetraphenylporphyrin and carbon nanocoil interface-based electrochemical sensing of tyrosine.

作者信息

Batool Bukhari Syeda Aqsa, Aziz Abeera, Nasir Habib, Ullah Sharif, Akhtar Tehmina, Iram Sadia, Sitara Effat, Mushtaq Shehla, Moiz Syed Abdul

机构信息

Department of Chemistry, School of Natural Sciences, National University of Sciences and Technology H-12 Islamabad 44000 Pakistan

Department of Chemistry, Rawalpindi Women University Rawalpindi Pakistan.

出版信息

RSC Adv. 2024 Aug 1;14(33):24105-24114. doi: 10.1039/d4ra02048k. eCollection 2024 Jul 26.

DOI:10.1039/d4ra02048k
PMID:39131187
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11313211/
Abstract

Tyrosine is one of the essential metabolites present in the human body for nutritional maintenance and normal physiological functioning. Its concentration in the body is crucial in predicting various hereditary, emotional, and physiological disorders. Therefore, quantitative monitoring of tyrosine in clinical samples is indispensable. We state the use of carbon nanocoils/manganese tetraphenylporphyrin convened glassy carbon electrode (CNC/MnTPP/GC) for the streamlined electrochemical sensing of tyrosine. Cutting-edge analytical techniques were employed to perform a comprehensive physicochemical analysis of the synthesized materials. To investigate the electrochemical properties, various techniques such as cyclic voltammetry (CV), differential pulse voltammetry (DPV), electrochemical impedance spectroscopy, and chronocoulometry were employed. CNC/MnTPP/GC displayed an optimal response at pH 5 and exhibited remarkable linearity within the concentration range of 0.05 to 100 μM for tyrosine. Using DPV, it demonstrated a low limit of detection (21 nM ± 1.17) and a sensitivity of 0.12 μA μM cm. CNC/MnTPP/GC displayed excellent performance in terms of repeatability, reproducibility, and stability for up to 30 days, making it suitable for real-time analysis, particularly in the analysis of tyrosine in blood serum. Notably, CNC/MnTPP/GC showcased a superior detection limit compared to previously reported methods.

摘要

酪氨酸是人体中存在的用于营养维持和正常生理功能的必需代谢物之一。其在体内的浓度对于预测各种遗传、情绪和生理紊乱至关重要。因此，临床样本中酪氨酸的定量监测必不可少。我们阐述了使用碳纳米线圈/四苯基卟啉锰修饰玻碳电极（CNC/MnTPP/GC）对酪氨酸进行简化的电化学传感。采用前沿分析技术对合成材料进行全面的物理化学分析。为研究其电化学性质，采用了多种技术，如循环伏安法（CV）、差分脉冲伏安法（DPV）、电化学阻抗谱和计时库仑法。CNC/MnTPP/GC在pH 5时显示出最佳响应，并且在酪氨酸浓度范围为0.05至100 μM时表现出显著的线性关系。使用DPV，它表现出低检测限（21 nM ± 1.17）和0.12 μA μM cm的灵敏度。CNC/MnTPP/GC在长达30天的重复性、重现性和稳定性方面表现出色，使其适用于实时分析，特别是在血清中酪氨酸的分析。值得注意的是，与先前报道的方法相比，CNC/MnTPP/GC展示了更低的检测限。

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