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免疫血栓形成:分子层面与新的治疗前景

Immunothrombosis: Molecular Aspects and New Therapeutic Perspectives.

作者信息

Marcos-Jubilar María, Lecumberri Ramón, Páramo José A

机构信息

Hematology and Hemotherapy Service, Clínica Universidad de Navarra, 31008 Pamplona, Spain.

CIBER-CV, Instituto de Salud Carlos III, 28029 Madrid, Spain.

出版信息

J Clin Med. 2023 Feb 9;12(4):1399. doi: 10.3390/jcm12041399.

Abstract

Thromboinflammation or immunothrombosis is a concept that explains the existing link between coagulation and inflammatory response present in many situations, such as sepsis, venous thromboembolism, or COVID-19 associated coagulopathy. The purpose of this review is to provide an overview of the current data regarding the mechanisms involved in immunothrombosis in order to understand the new therapeutic strategies focused in reducing thrombotic risk by controlling the inflammation.

摘要

血栓炎症或免疫血栓形成是一个概念,它解释了在许多情况下,如脓毒症、静脉血栓栓塞或新冠病毒相关凝血病中,凝血与炎症反应之间存在的联系。本综述的目的是概述目前关于免疫血栓形成所涉及机制的数据,以便理解通过控制炎症来降低血栓形成风险的新治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06a6/9958829/89bd9154163b/jcm-12-01399-g001.jpg

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