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免疫血栓形成:分子层面与新的治疗前景

Immunothrombosis: Molecular Aspects and New Therapeutic Perspectives.

作者信息

Marcos-Jubilar María, Lecumberri Ramón, Páramo José A

机构信息

Hematology and Hemotherapy Service, Clínica Universidad de Navarra, 31008 Pamplona, Spain.

CIBER-CV, Instituto de Salud Carlos III, 28029 Madrid, Spain.

出版信息

J Clin Med. 2023 Feb 9;12(4):1399. doi: 10.3390/jcm12041399.

DOI:10.3390/jcm12041399
PMID:36835934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9958829/
Abstract

Thromboinflammation or immunothrombosis is a concept that explains the existing link between coagulation and inflammatory response present in many situations, such as sepsis, venous thromboembolism, or COVID-19 associated coagulopathy. The purpose of this review is to provide an overview of the current data regarding the mechanisms involved in immunothrombosis in order to understand the new therapeutic strategies focused in reducing thrombotic risk by controlling the inflammation.

摘要

血栓炎症或免疫血栓形成是一个概念,它解释了在许多情况下,如脓毒症、静脉血栓栓塞或新冠病毒相关凝血病中,凝血与炎症反应之间存在的联系。本综述的目的是概述目前关于免疫血栓形成所涉及机制的数据,以便理解通过控制炎症来降低血栓形成风险的新治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06a6/9958829/89bd9154163b/jcm-12-01399-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06a6/9958829/89bd9154163b/jcm-12-01399-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06a6/9958829/89bd9154163b/jcm-12-01399-g001.jpg

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本文引用的文献

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The coming of age of neutrophil extracellular traps in thrombosis: Where are we now and where are we headed?中性粒细胞胞外诱捕网在血栓形成中的成熟:我们现在在哪里,我们的目标在哪里?
Immunol Rev. 2023 Mar;314(1):376-398. doi: 10.1111/imr.13179. Epub 2022 Dec 22.
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Dysregulated haemostasis in thrombo-inflammatory disease.血栓炎症性疾病中的血液失调。
Clin Sci (Lond). 2022 Dec 22;136(24):1809-1829. doi: 10.1042/CS20220208.
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Thromboinflammation: From Atherosclerosis to COVID-19.血栓炎症:从动脉粥样硬化到 COVID-19。
孕妇感染严重急性呼吸综合征冠状病毒2型与血栓栓塞性疾病的发生率:德国新冠病毒相关产科和新生儿结局研究(CRONOS)分析
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Medicine (Baltimore). 2024 Oct 11;103(41):e39915. doi: 10.1097/MD.0000000000039915.
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