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“给我开合适剂量的药”:解决抗菌药物剂量不足这一关键问题以应对尼日利亚的抗菌药物耐药性

'Cut medicine for me': addressing suboptimal dosing of antimicrobials as a critical issue to combat AMR in Nigeria.

作者信息

Egwu Kenneth Chukwuebuka, Abdulkarim Maryam, Eze Shadrach Chinecherem, Mbamalu Oluchi

机构信息

Department of Pharmacy, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu State, Nigeria.

Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, UK.

出版信息

JAC Antimicrob Resist. 2024 Aug 9;6(4):dlae131. doi: 10.1093/jacamr/dlae131. eCollection 2024 Aug.

Abstract

Antimicrobial resistance (AMR) is a critical health challenge in Nigeria as in many other countries in the sub-Saharan region of Africa. Our article describes how the challenges in the regulation and operations of Patent and Proprietary Medicine Vendors (PPMVs) in Nigeria provide a blind spot for the underuse of antimicrobials. This article also sheds light on how patients' antibiotic use and seeking behaviour facilitate this unwholesome practice. In addition, our article looks at the social determinants of this practice, such as poverty and poor education, and proffers solutions towards solving it. While previous research has investigated the knowledge, perceptions and attitudes of PPMVs towards antimicrobial use and AMR, our article is the first to critically raise concerns about the common practice of antimicrobial underdosing in Nigeria.

摘要

与撒哈拉以南非洲地区的许多其他国家一样,抗菌药物耐药性(AMR)是尼日利亚面临的一项严峻的健康挑战。我们的文章描述了尼日利亚专利和成药销售商(PPMVs)在监管和运营方面的挑战如何成为抗菌药物使用不足的一个盲点。本文还揭示了患者的抗生素使用和就医行为如何助长了这种不良做法。此外,我们的文章探讨了这种做法的社会决定因素,如贫困和教育程度低,并提出了解决方案。虽然之前的研究调查了PPMVs对抗菌药物使用和AMR的知识、认知和态度,但我们的文章首次批判性地关注了尼日利亚抗菌药物剂量不足的普遍现象。

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