Validation of a phenotyping method to identify porcine reproductive and respiratory syndrome virus-resilient sows and its impact on sow stayability.

Endemic and epidemic outbreaks of porcine reproductive and respiratory syndrome virus (PRRSV) are causing large economic losses in commercial pig production worldwide. Given the complexity of controlling this disease with vaccines or other biosecurity measures, the selection of pigs with a natural resilience to this infection has been proposed as an alternative approach. In this context, we previously reported a vaccine-based protocol to classify 6-wk-old female piglets from one farm into resilient and susceptible phenotypes. Subsequent analysis showed that resilient sows had fewer lost piglets during a PRRSV epidemic. In the present study, we validated the results in four additional farms by showing a robust effect on the percentage of piglets lost (P < 0.05). We were able to associate the resilient phenotype with a 2% to 4% reduction in piglet losses on sow farms in both endemic and endemic/epidemic situations. Also consistent with previous results, susceptible sows delivered on average, almost 0.5 more piglets born per parity (P < 0.05). However, we show here that resilient sows have a longer stayability in the farm (+57 d; P < 0.05) and +0.3 more successful parities (P < 0.05), which balances the total number of piglets born and born alive in the full productive life of the sow between the two groups. Resilient sows thus contribute towards a more sustainable production system, reducing sow replacement and piglet mortality. The validation of this protocol on four independent production farms paves the way for the study of the genetic variation underlying the resilient/susceptible classification, with a view to incorporating this information into selection programs in the future.