Vella Szijj Janis
Department of Pharmacy, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.
Cannabis Cannabinoid Res. 2024 Dec;9(6):1470-1477. doi: 10.1089/can.2024.0087. Epub 2024 Aug 12.
Accurate and precise analysis of cannabinoids is important for elucidating their therapeutic potential and developing therapies, which are targeted toward different medical conditions. A wide range of cannabis products are present on the market and are available in different dosage forms, including dried flowers, extracts, and consumables. The aim of this article is to provide an updated narrative review of literature on challenges of analyzing cannabinoids in plant material, oils, and edibles. Literature search was conducted to identify sample preparation and analytical techniques for determination of cannabinoids in plant material, oils, and edibles and associated challenges. Challenges related to determination of cannabinoids in plant material include matrix complexity, co-extraction of unwanted compounds during sample preparation, and differences in matrix composition between calibration standards and sample extracts. During analysis of cannabinoids in oil, the unique properties of carrier oils need to be taken into consideration. Analysis of cannabinoids in edibles can be considered to be challenging due to the wide range of matrix types that are available on the market, rendering analysis resource-intensive, time-consuming, and impractical. Analysis of cannabinoids in plant material, oils, and edibles requires a multifaceted approach that includes regulatory guidance, method development, and technological innovation. In the face of an evolving analytical landscape where novel cannabinoids are being identified and require determination, there is a need for the development and validation of standardized accurate and precise analytical methods, which are specifically tailored for each matrix.
准确且精确地分析大麻素对于阐明其治疗潜力以及开发针对不同医疗状况的疗法至关重要。市场上存在各种各样的大麻产品，且有不同的剂型，包括干花、提取物和可食用产品。本文的目的是对有关分析植物材料、油类和可食用产品中大麻素的挑战的文献进行最新的叙述性综述。进行文献检索以确定用于测定植物材料、油类和可食用产品中大麻素的样品制备和分析技术以及相关挑战。与测定植物材料中大麻素相关的挑战包括基质复杂性、样品制备过程中不需要的化合物的共提取以及校准标准品和样品提取物之间基质组成的差异。在分析油类中的大麻素时，需要考虑载体油的独特性质。由于市场上可获得的基质类型广泛，使得对可食用产品中大麻素的分析具有挑战性，这使得分析资源密集、耗时且不切实际。分析植物材料、油类和可食用产品中的大麻素需要一种多方面的方法，包括监管指导、方法开发和技术创新。面对不断演变的分析格局，其中新的大麻素不断被识别并需要进行测定，需要开发和验证标准化的准确且精确的分析方法，这些方法是专门针对每种基质量身定制的。
