Center for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Center for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
J Affect Disord. 2024 Nov 1;364:146-156. doi: 10.1016/j.jad.2024.08.006. Epub 2024 Aug 10.
The burden of major depressive disorder is compounded by a limited understanding of its risk factors, the limited efficacy of treatments, and the lack of precision approaches to guide treatment selection. The Texas Resilience Against Depression (T-RAD) study was designed to explore the etiology of depression by collecting comprehensive socio-demographic, clinical, behavioral, neurophysiological/neuroimaging, and biological data from depressed individuals (D2K) and youth at risk for depression (RAD).
This report details the baseline sociodemographic, clinical, and functional features from the initial cohort (D2K N = 1040, RAD N = 365).
Of the total T-RAD sample, n = 1078 (76.73 %) attended ≥2 in-person visits, and n = 845 (60.14 %) attended ≥4 in-person visits. Most D2K (84.82 %) had a primary diagnosis of any depressive disorder, with a bipolar disorder diagnosis being prevalent (13.49 %). RAD participants (75.89 %) did not have a psychiatric diagnosis, but other non-depressive diagnoses were present. D2K participants had 9-item Patient Health Questionnaire scores at or near the moderate range (10.58 ± 6.42 > 24 yrs.; 9.73 ± 6.12 10-24 yrs). RAD participants were in the non-depressed range (2.19 ± 2.65). While the age ranges in D2K and RAD differ, the potential to conduct analyses that compare at-risk and depressed youth is a strength of the study. The opportunity to examine the trajectory of depressive symptoms in the D2K cohort over the lifespan is unique.
As a longitudinal study, missing data were common.
T-RAD will allow data to be collected from multiple modalities on a clinically well-characterized sample. These data will drive important discoveries on diagnosis, treatment, and prevention of depression.
由于对其危险因素、治疗效果有限以及缺乏指导治疗选择的精准方法的认识有限，导致重度抑郁症的负担加重。德克萨斯州抗抑郁能力研究（T-RAD）旨在通过收集抑郁患者（D2K）和有抑郁风险的青少年（RAD）的综合社会人口统计学、临床、行为、神经生理学/神经影像学和生物学数据来探索抑郁的病因。
本报告详细介绍了初始队列的基线社会人口统计学、临床和功能特征（D2K N=1040，RAD N=365）。
在 T-RAD 总样本中，n=1078（76.73%）参加了≥2 次面对面就诊，n=845（60.14%）参加了≥4 次面对面就诊。大多数 D2K（84.82%）有任何抑郁障碍的主要诊断，双相障碍诊断较为常见（13.49%）。RAD 参与者（75.89%）没有精神科诊断，但存在其他非抑郁性诊断。D2K 参与者的 9 项患者健康问卷评分在中等到接近中度范围（24 岁以上者为 10.58±6.42，10-24 岁者为 9.73±6.12）。RAD 参与者处于非抑郁状态（2.19±2.65）。虽然 D2K 和 RAD 的年龄范围不同，但该研究的一个优势是有潜力比较有风险和抑郁的青少年。D2K 队列中在整个生命周期内检查抑郁症状轨迹的机会是独特的。
作为一项纵向研究，数据缺失很常见。
T-RAD 将允许从多种模式收集具有临床特征的样本数据。这些数据将推动对抑郁症的诊断、治疗和预防的重要发现。
