Nandy Karabi, Goodman Lynnel C, Mayes Taryn L, Ayvaci Emine Rabia, Trombello Joseph M, Elmore Joshua S, Vasu Srividya, Emslie Graham J, Trivedi Madhukar H
Center for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Neuropsychiatr Dis Treat. 2025 Aug 20;21:1703-1716. doi: 10.2147/NDT.S529377. eCollection 2025.
Suicide prevention requires reliable assessment tools, integrating the Food and Drug Administration (FDA)-endorsed Columbia Classification Algorithm of Suicide Assessment domains and psychological risk factors, capturing patient-reported experiences and clinician-reported characterizations of suicidality comprehensively. The 9-item Concise Health Risk Tracking - Self-Report (CHRT-SR) is a patient-reported outcome that was designed to capture suicide-related constructs such as pessimism, helplessness, despair, and suicidal thinking/planning. The semi-structured, clinician-administered CHRT-Behavior (CHRT-Beh) scale was created to capture recent suicidal events (ideation and behaviors) in alignment with the FDA-endorsed system for coding suicidality. In this report, we present a two-step approach for assessing suicidality and provide preliminary data for the dual use of the CHRT-SR and CHRT-Beh.
Data from the Texas Resilience Against Depression (T-RAD) cohort were used for the analysis. T-RAD consists of two datasets, one with participants with a history of depression and healthy controls (D2K, n=1040, ages 10 and above) and one with youth ages 10-24 years at risk for depression (RAD, n=365). Participants completed both the CHRT-SR and CHRT-Beh at study entry.
Using the CHRT-Beh, a subset of D2K participants aged ≥ 24 years reported suicidal ideation (14.07%), non-suicidal self-injury (1.11%), and self-injurious behavior (0.28%) in the past week. Findings were similar in D2K participants aged 10-24 years. A subset of RAD participants (1.64%) reported suicidal ideation without attempt or self-injurious behavior in the past week. Participants who reported suicidal ideation on the CHRT-Beh had significantly higher CHRT-SR total scores (17.1 ±7.4 vs 5.6 ±6.2; p<0.0001) and CHRT-SR suicidal ideation subscale scores (4.0 ±3.1 vs 0.6 ±1.7; p<0.0001) than those without suicidal ideation.
The co-administration of CHRT-SR and CHRT-Beh provides researchers with a suicidality risk measure and a retrospective assessment of suicidal behaviors. The CHRT-SR and CHRT-Beh package provides a holistic clinical evaluation of suicidal risk meeting regulatory requirements.
自杀预防需要可靠的评估工具,整合美国食品药品监督管理局(FDA)认可的哥伦比亚自杀评估分类算法中的各个领域以及心理风险因素,全面捕捉患者报告的经历和临床医生报告的自杀倾向特征。9项简明健康风险追踪 - 自我报告(CHRT - SR)是一种患者报告结局,旨在捕捉与自杀相关的概念,如悲观、无助、绝望以及自杀想法/计划。半结构化的、由临床医生实施的CHRT - 行为(CHRT - Beh)量表旨在根据FDA认可的自杀倾向编码系统捕捉近期自杀事件(想法和行为)。在本报告中,我们提出一种评估自杀倾向的两步法,并提供CHRT - SR和CHRT - Beh双重用途的初步数据。
来自德克萨斯抗抑郁复原力(T - RAD)队列的数据用于分析。T - RAD由两个数据集组成,一个数据集包含有抑郁症病史的参与者和健康对照(D2K,n = 1040,年龄10岁及以上),另一个数据集包含10 - 24岁有抑郁症风险的青少年(RAD,n = 365)。参与者在研究开始时完成了CHRT - SR和CHRT - Beh。
使用CHRT - Beh,D2K中年龄≥24岁的一部分参与者报告在过去一周有自杀想法(14.07%)、非自杀性自伤(1.11%)和自伤行为(0.28%)。10 - 24岁的D2K参与者中也有类似结果。RAD中的一部分参与者(1.64%)报告在过去一周有自杀想法但无自杀未遂或自伤行为。在CHRT - Beh上报告有自杀想法的参与者的CHRT - SR总分(17.1±7.4 vs 5.6±6.2;p<0.0001)和CHRT - SR自杀想法子量表得分(4.0±3.1 vs 0.6±1.7;p<0.0001)显著高于无自杀想法的参与者。
CHRT - SR和CHRT - Beh的联合使用为研究人员提供了一种自杀倾向风险测量方法以及对自杀行为的回顾性评估。CHRT - SR和CHRT - Beh组合提供了符合监管要求的自杀风险整体临床评估。