University of Bristol, Bristol, England.
Can J Health Hist. 2023 Sep;40(2):370-393. doi: 10.3138/cjhh.637-032023. Epub 2023 Jul 24.
John James Rickard Macleod provided the facilities and support that enabled Frederick Banting and Charles Best to perform the experimental work that resulted in the discovery of insulin. This review considers Macleod's intellectual contribution to the initial discovery in light of his previously expressed opinions on glucose metabolism. He acknowledged the likely existence of an internal secretion from the pancreas and was aware of previous work in the area; however, seeking it was not among his research priorities. His advice in the immediate aftermath of the discovery does not appear to have made any essential contribution to the project, although he made its ultimate success possible. Instead, he gave Banting the chance he needed, gave him full credit for what he achieved, and promoted insulin tirelessly as a gift to the world.
约翰·詹姆斯·里卡顿·麦克劳德提供了设施和支持，使弗雷德里克·班廷和查尔斯·贝斯特能够进行实验工作，从而发现了胰岛素。这篇综述考虑了麦克劳德在最初发现中的智力贡献，以及他之前对葡萄糖代谢的看法。他承认胰腺可能存在内分泌，并了解该领域的先前工作；然而，寻找它并不是他的研究重点之一。他在发现后的建议似乎并没有对该项目做出任何重要贡献，尽管他使该项目最终取得了成功。相反，他给了班廷所需要的机会，充分肯定了他所取得的成就，并不懈地宣传胰岛素，将其作为一份礼物献给了全世界。
