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Chimeric antigen receptor T-cell therapy associated hemophagocytic lymphohistiocytosis syndrome: clinical presentation, outcomes, and management.

作者信息

Khurana Arushi, Rosenthal Allison C, Mohty Razan, Gaddam Mamatha, Bansal Radhika, Hathcock Matthew A, Nedved Adrienne N, Durani Urshila, Iqbal Madiha, Wang Yucai, Paludo Jonas, Villasboas J C, Dingli David, Kourelis Taxiarchis, Leung Nelson, Alkhateeb Hassan, Ruff Michael W, Gallo de Moraes Alice, Vergidis Paschalis, Herrmann Joerg, Kenderian Saad S, Bennani N Nora, Johnston Patrick B, Ansell Stephen M, Lin Yi

机构信息

Division of Hematology Mayo Clinic, Rochester, MN, USA.

Division of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ, USA.

出版信息

Blood Cancer J. 2024 Aug 12;14(1):136. doi: 10.1038/s41408-024-01119-2.

DOI:10.1038/s41408-024-01119-2
PMID:39134524
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11319601/
Abstract
摘要

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Transplant Cell Ther. 2023 Jul;29(7):438.e1-438.e16. doi: 10.1016/j.jtct.2023.03.006. Epub 2023 Mar 9.
2
Single-center experience using anakinra for steroid-refractory immune effector cell-associated neurotoxicity syndrome (ICANS).单中心应用阿那白滞素治疗类固醇难治性免疫效应细胞相关性神经毒性综合征(ICANS)的经验。
J Immunother Cancer. 2022 Jan;10(1). doi: 10.1136/jitc-2021-003847.
3
Characterization of HLH-like manifestations as a CRS variant in patients receiving CD22 CAR T cells.描述接受 CD22 CAR T 细胞治疗的患者中以细胞因子释放综合征(CRS)为表现形式的噬血细胞淋巴组织细胞增生症(HLH)样综合征。
Blood. 2021 Dec 16;138(24):2469-2484. doi: 10.1182/blood.2021011898.
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Hemophagocytic lymphohistiocytosis-like toxicity (carHLH) after CD19-specific CAR T-cell therapy.CD19 特异性嵌合抗原受体 T 细胞治疗后噬血细胞性淋巴组织细胞增生症样毒性(carHLH)。
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Crit Care Explor. 2021 Jun 29;3(7):e0472. doi: 10.1097/CCE.0000000000000472. eCollection 2021 Jul.
6
Continuous renal replacement therapy in cytokine release syndrome following immunotherapy or cellular therapies?免疫治疗或细胞治疗后细胞因子释放综合征中的持续肾脏替代治疗?
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Diagnosis and Management of Secondary HLH/MAS Following HSCT and CAR-T Cell Therapy in Adults; A Review of the Literature and a Survey of Practice Within EBMT Centres on Behalf of the Autoimmune Diseases Working Party (ADWP) and Transplant Complications Working Party (TCWP).成人造血干细胞移植和嵌合抗原受体T细胞疗法后继发性噬血细胞性淋巴组织细胞增生症/巨噬细胞活化综合征的诊断与管理;文献综述及代表自身免疫性疾病工作组(ADWP)和移植并发症工作组(TCWP)对欧洲血液和骨髓移植协会(EBMT)中心的实践调查
Front Immunol. 2020 Mar 31;11:524. doi: 10.3389/fimmu.2020.00524. eCollection 2020.
8
CD4/CD8 T-Cell Selection Affects Chimeric Antigen Receptor (CAR) T-Cell Potency and Toxicity: Updated Results From a Phase I Anti-CD22 CAR T-Cell Trial.CD4/CD8 T 细胞选择影响嵌合抗原受体(CAR)T 细胞效力和毒性:一项抗 CD22 CAR T 细胞试验的 I 期更新结果。
J Clin Oncol. 2020 Jun 10;38(17):1938-1950. doi: 10.1200/JCO.19.03279. Epub 2020 Apr 14.
9
Haemophagocytic lymphohistiocytosis has variable time to onset following CD19 chimeric antigen receptor T cell therapy.噬血细胞性淋巴组织细胞增生症在接受CD19嵌合抗原受体T细胞治疗后发病时间不一。
Br J Haematol. 2019 Oct;187(2):e35-e38. doi: 10.1111/bjh.16155. Epub 2019 Aug 13.
10
Recommendations for the management of hemophagocytic lymphohistiocytosis in adults.成人噬血细胞性淋巴组织细胞增生症的治疗建议。
Blood. 2019 Jun 6;133(23):2465-2477. doi: 10.1182/blood.2018894618. Epub 2019 Apr 16.