Ihler G M, Tsang H C
Crit Rev Ther Drug Carrier Syst. 1985;1(2):155-87.
The properties of erythrocytes used as carriers for drugs, enzymes, and DNA will be reviewed. One potential application is delivery of these substances to cells responsible for or capable of erythrophagocytosis and are located primarily in the liver and the spleen. A second potential application depends on the ability of loaded cells to survive for substantial periods of time in the circulation after reinfusion. Circulating cells used as drug carriers may be able to modify the pharmacokinetics of administered drugs and if used as enzyme carriers, they may be able to alter the level of various substances in the plasma. Erythrocytes in vitro may fuse with recipient cells, introducing their contents in a functional form into recipient cells. Nucleic acids, either RNA or DNA, as well as enzymes or other entrapped substances, may be transferred in this manner.
将对用作药物、酶和DNA载体的红细胞的特性进行综述。一个潜在应用是将这些物质递送至主要位于肝脏和脾脏中负责或能够进行红细胞吞噬作用的细胞。第二个潜在应用取决于负载细胞在再输注后在循环中长时间存活的能力。用作药物载体的循环细胞可能能够改变所给药药物的药代动力学，而如果用作酶载体，它们可能能够改变血浆中各种物质的水平。体外红细胞可能与受体细胞融合，将其内含物以功能形式引入受体细胞。核酸，无论是RNA还是DNA，以及酶或其他截留物质，都可以以这种方式转移。
