含肌醇六磷酸的红细胞观察到寄生虫血症降低。
Reduced parasitemia observed with erythrocytes containing inositol hexaphosphate.
作者信息
Mintzer C L, Deloron P, Rice-Ficht A, Durica D, Struck D K, Roessner C A, Nicolau C, Ihler G M
机构信息
Department of Medical Biochemistry and Genetics, Texas A & M College of Medicine, College Station.
出版信息
Antimicrob Agents Chemother. 1988 Mar;32(3):391-4. doi: 10.1128/AAC.32.3.391.
Abstract
Chemicals entrapped in erythrocytes by hypotonic hemolysis can be assessed for possible antiparasitic activity both in vivo and in vitro, regardless of whether they are able to diffuse into erythrocytes readily. Inositol hexaphosphate, a highly charged compound, produced a dramatic lowering of the percentage of cells infected by Babesia microti in vivo and both B. microti and Plasmodium falciparum in vitro. Several possible mechanisms for this observation are discussed.
摘要
通过低渗溶血被困在红细胞中的化学物质，无论它们是否能够轻易扩散到红细胞中，均可在体内和体外评估其可能的抗寄生虫活性。肌醇六磷酸是一种高电荷化合物，它在体内使微小巴贝斯虫感染的细胞百分比显著降低，在体外使微小巴贝斯虫和恶性疟原虫感染的细胞百分比显著降低。本文讨论了对此观察结果的几种可能机制。
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本文引用的文献
1
Protection afforded by sickle-cell trait against subtertian malareal infection.镰状细胞性状对间日疟感染的保护作用。
Br Med J. 1954 Feb 6;1(4857):290-4. doi: 10.1136/bmj.1.4857.290.
2
Babesia bovis: continuous cultivation in a microaerophilous stationary phase culture.牛巴贝斯虫：在微需氧固定相培养物中的连续培养
Science. 1980 Mar 14;207(4436):1218-20. doi: 10.1126/science.7355284.
3
Cryopreservation of Babesia bovis for in vitro cultivation.用于体外培养的牛巴贝斯虫的冷冻保存。
Parasitology. 1982 Jun;84(Pt 3):567-72. doi: 10.1017/s0031182000052835.
4
Plasmodium falciparum in vitro: determination of chloroquine sensitivity of three new strains by a modified 48-hour test.恶性疟原虫体外培养：采用改良的48小时试验测定三株新菌株对氯喹的敏感性
Am J Trop Med Hyg. 1980 May;29(3):339-42. doi: 10.4269/ajtmh.1980.29.339.
5
Effects of Ca++ depletion on the asexual cell cycle of Plasmodium falciparum.钙离子耗竭对恶性疟原虫无性细胞周期的影响。
Am J Trop Med Hyg. 1982 Jul;31(4):711-7. doi: 10.4269/ajtmh.1982.31.711.
6
Antibodies in malarial sera to parasite antigens in the membrane of erythrocytes infected with early asexual stages of Plasmodium falciparum.疟疾血清中针对恶性疟原虫早期无性阶段感染的红细胞膜内寄生虫抗原的抗体。
J Exp Med. 1984 Jun 1;159(6):1686-704. doi: 10.1084/jem.159.6.1686.
7
Erythrocyte carriers.红细胞载体
Pharmacol Ther. 1983;20(2):151-69. doi: 10.1016/0163-7258(83)90037-2.
8
A cytoplasmic requirement of red cells for invasion by malarial parasites.疟原虫入侵红细胞的细胞质需求。
Mol Biochem Parasitol. 1983 Oct;9(2):145-60. doi: 10.1016/0166-6851(83)90106-8.
9
Inhibition of the in vitro growth of Plasmodium falciparum by D vitamins and vitamin D-3 derivatives.D族维生素和维生素D-3衍生物对恶性疟原虫体外生长的抑制作用。
Mol Biochem Parasitol. 1982 Mar;5(3):189-98. doi: 10.1016/0166-6851(82)90020-2.
10
Reciprocal binding of oxygen and diphosphoglycerate by human hemoglobin.人血红蛋白对氧和二磷酸甘油酸的相互结合作用。
Proc Natl Acad Sci U S A. 1968 Feb;59(2):526-32. doi: 10.1073/pnas.59.2.526.
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