Mintzer C L, Deloron P, Rice-Ficht A, Durica D, Struck D K, Roessner C A, Nicolau C, Ihler G M
Department of Medical Biochemistry and Genetics, Texas A & M College of Medicine, College Station.
Antimicrob Agents Chemother. 1988 Mar;32(3):391-4. doi: 10.1128/AAC.32.3.391.
Chemicals entrapped in erythrocytes by hypotonic hemolysis can be assessed for possible antiparasitic activity both in vivo and in vitro, regardless of whether they are able to diffuse into erythrocytes readily. Inositol hexaphosphate, a highly charged compound, produced a dramatic lowering of the percentage of cells infected by Babesia microti in vivo and both B. microti and Plasmodium falciparum in vitro. Several possible mechanisms for this observation are discussed.
通过低渗溶血被困在红细胞中的化学物质，无论它们是否能够轻易扩散到红细胞中，均可在体内和体外评估其可能的抗寄生虫活性。肌醇六磷酸是一种高电荷化合物，它在体内使微小巴贝斯虫感染的细胞百分比显著降低，在体外使微小巴贝斯虫和恶性疟原虫感染的细胞百分比显著降低。本文讨论了对此观察结果的几种可能机制。
