Kosugi Yasuo, Murakami Naoya, Muramoto Yoichi, Karino Tatsuki, Oshima Masaki, Kawamoto Terufumi, Motomura Hiroaki, Nakazawa Shun, Koinuma Yoshika, Ohba Shinichi, Matsumoto Fumihiko, Shikama Naoto
Department of Radiation Oncology, Juntendo University Graduate School of Medicine, Japan.
Department of Respiratory Medicine, Faculty of Medicine, Juntendo University, Japan.
Intern Med. 2025 Mar 15;64(6):905-910. doi: 10.2169/internalmedicine.4067-24. Epub 2024 Aug 10.
Hangeshashinto is a traditional Japanese herbal medicine that is widely recognized for its efficacy in relieving mucositis induced by chemotherapy and radiotherapy. We herein present the cases of two patients with head and neck cancer who were clinically diagnosed with severe drug-induced interstitial lung disease (DILD) following Hangeshashinto administration for radiation-induced mucositis. Although Hangeshashinto has beneficial properties, it is also associated with a relatively low incidence of DILD, including some reports of death. To ensure patient safety, greater attention should be paid when prescribing Hangeshashinto, especially for elderly patients with factors predisposing them to develop severe DILD.
汉方柴胡汤是一种传统的日本草药，因其在缓解化疗和放疗引起的粘膜炎方面的功效而被广泛认可。我们在此报告两例头颈部癌患者的病例，他们在服用汉方柴胡汤治疗放射性粘膜炎后，临床诊断为严重药物性间质性肺病（DILD）。尽管汉方柴胡汤有有益的特性，但它也与相对较低的DILD发生率相关，包括一些死亡报告。为确保患者安全，在开汉方柴胡汤处方时应格外注意，尤其是对于有易发生严重DILD因素的老年患者。
