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同种异体骨与富血小板纤维蛋白用于牙槽裂植骨的骨学转归:影像学结果的初步研究

Osseous Outcomes of Cleft Alveolar Bone Grafting with Allograft and Platelet-Rich Fibrin: Preliminary Study with Radiological Outcome.

作者信息

Chauvel-Picard Julie, Lambert Camille, Gaget Dominique, Asselborn Marc, Lange Edouard, Gleizal Arnaud

机构信息

Department of Pediatric Cranio-Maxillo-Facial Surgery, Hôpital Femme Mère Enfant, Lyon Bron, France.

Department of Cranio-Maxillo-Facial Surgery, Centre Hospitalo-Universitaire Nord, Saint-Etienne, France.

出版信息

Cleft Palate Craniofac J. 2025 Sep;62(9):1549-1554. doi: 10.1177/10556656241271663. Epub 2024 Aug 12.

Abstract

ObjectiveCleft lip and palate are the most common craniofacial malformations worldwide. The alveolar cleft is treated with a bone graft, between 4 and 7 years of age in mixed dentition. This is an important step because it provides good quality jawbone and a better support of the lip and the alar cartilage on the side of the cleft. Bone autografting with iliac harvesting remains the most commonly used technique, but it is not without risks. Allograft techniques have therefore been described to reduce this morbidity (pain, infectious risk, hemorrhagic risk, fracture risk). The aim of this study was to evaluate, one year after allografting, the efficiency and consolidation of the bone allograft in the alveolar cleft.SettingA retrospective study was conducted in the department of pediatric craniomaxillofacial surgery in the Woman-Mother-Child Hospital in Lyon, France.PatientsThis series includes 22 patients or 25 alveolar cleft bone grafts, including 16 boys and 6 girls, with an average age of 6.1 years.Main Outcome MeasuresQuantify the residual bone allograft by evaluating the ratio between the volume of the bone graft and the volume of the initial space on pre- and post-operative cone beam computed tomography.ResultsThe residual bone allograft percentage at 1 year was 58.5% (± 22.3).ConclusionsAlveolar cleft bone graft with bone allograft is an alternative to iliac autografting to reduce donor site morbidity.

摘要

目的

唇腭裂是全球最常见的颅面畸形。牙槽裂在混合牙列期4至7岁时采用骨移植治疗。这是重要的一步,因为它能提供高质量的颌骨,并更好地支撑腭裂侧的唇部和鼻翼软骨。取自髂骨的自体骨移植仍是最常用的技术,但并非没有风险。因此,已描述了同种异体骨移植技术以降低这种发病率(疼痛、感染风险、出血风险、骨折风险)。本研究的目的是在同种异体骨移植一年后,评估牙槽裂同种异体骨移植的有效性和骨愈合情况。

背景

在法国里昂的妇女儿童医院小儿颅颌面外科进行了一项回顾性研究。

患者

该系列包括22例患者或25处牙槽裂骨移植,其中16名男孩和6名女孩,平均年龄6.1岁。

主要观察指标

通过评估术前和术后锥形束计算机断层扫描上骨移植体积与初始间隙体积的比率,量化残留的同种异体骨。

结果

1年时残留同种异体骨的百分比为58.5%(±22.3)。

结论

牙槽裂骨移植采用同种异体骨是减少供区发病率的髂骨自体移植的替代方法。

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