MASS队列研究：关于微生物群在重症肺炎及宿主易感性中作用的多中心、纵向、前瞻性研究。
MASS cohort: Multicenter, longitudinal, and prospective study of the role of microbiome in severe pneumonia and host susceptibility.
作者信息
Wei Xin, Guo Li, Cai Hongliu, Gu Silan, Tang Lingling, Leng Yuxin, Cheng Minghui, He Guojun, Han Yijiao, Ren Xindie, Lin Baoyue, Lv Longxian, Shao Huanzhang, Wang Mingqiang, Wang Hongyu, Dang Dan, Wang Shengfeng, Wang Nan, Shen Peng, Wang Qianqian, Xu Yinghe, Jiang Yongpo, Zhang Ning, He Xuwei, Deng Xuntao, Dai Muhua, Zhong Lin, Xiong Yonghui, Pan Yujie, Tang Kankai, Liu Fengqi, Yang Bin, Ren Lili, Wang Jianwei, Jiang Chao, Huang Lingtong
机构信息
Life Sciences Institute and Department of Critical Care Medicine of First Affiliated Hospital Zhejiang University Hangzhou China.
NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, National Institute of Pathogen Biology Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.
出版信息
Imeta. 2024 Jun 25;3(4):e218. doi: 10.1002/imt2.218. eCollection 2024 Aug.
The MASS cohort comprises 2000 ICU patients with severe pneumonia, covering community-acquired pneumonia, hospital-acquired pneumonia, and ventilator-associated pneumonia, sourced from 19 hospitals across 10 cities in three provinces. A wide array of samples including bronchoalveolar lavage fluid, sputum, feces, and whole blood are longitudinally collected throughout patients' ICU stays. The cohort study seeks to uncover the dynamics of lung and gut microbiomes and their associations with severe pneumonia and host susceptibility, integrating deep metagenomics and transcriptomics with detailed clinical data.
MASS队列包括2000名患有严重肺炎的重症监护病房患者，涵盖社区获得性肺炎、医院获得性肺炎和呼吸机相关性肺炎，这些患者来自三个省份10个城市的19家医院。在患者整个重症监护病房住院期间，纵向收集了包括支气管肺泡灌洗液、痰液、粪便和全血在内的大量样本。该队列研究旨在揭示肺和肠道微生物群的动态变化及其与严重肺炎和宿主易感性的关联，将深度宏基因组学和转录组学与详细的临床数据相结合。
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