Zhou Xin, Liu Jinyu, Wu Feifeng, Mao Jueyi, Wang Yang, Zhu Junquan, Hong Kimsor, Xie Haotian, Li Binbin, Qiu Xinying, Xiao Xiangbin, Wen Chuan
Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, China.
Department of Obstetrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Front Bioeng Biotechnol. 2024 Jul 29;12:1434465. doi: 10.3389/fbioe.2024.1434465. eCollection 2024.
The immune system, functioning as the body's "defense army", plays a role in surveillance, defense. Any disruptions in immune system can lead to the development of immune-related diseases. Extensive researches have demonstrated the crucial immunoregulatory role of mesenchymal stem cells (MSCs) in these diseases. Of particular interest is the ability to induce somatic cells under specific conditions, generating a new cell type with stem cell characteristics known as induced pluripotent stem cell (iPSC). The differentiation of iPSCs into MSCs, specifically induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs), hold promise as a potential solution to the challenges of MSCs, potentially serving as an alternative to traditional drug therapies. Moreover, the products of iMSCs, termed induced pluripotent stem cell-derived mesenchymal stem cell-derived extracellular vesicles (iMSC-EVs), may exhibit functions similar to iMSCs. With the biological advantages of EVs, they have become the focus of "cell-free therapy". Here, we provided a comprehensive summary of the biological impact of iMSCs on immune cells, explored the applications of iMSCs and iMSC-EVs in diseases, and briefly discussed the fundamental characteristics of EVs. Finally, we overviewed the current advantages and challenges associated with iMSCs and iMSC-EVs. It is our hope that this review related to iMSCs and iMSC-EVs will contribute to the development of new approaches for the treatment of diseases.
免疫系统作为人体的“防御部队”，在监测、防御方面发挥作用。免疫系统的任何紊乱都可能导致免疫相关疾病的发生。广泛的研究已经证明间充质干细胞（MSCs）在这些疾病中具有关键的免疫调节作用。特别值得关注的是在特定条件下诱导体细胞的能力，从而产生一种具有干细胞特征的新细胞类型，即诱导多能干细胞（iPSC）。iPSC分化为MSCs，特别是诱导多能干细胞衍生的间充质干细胞（iMSCs），有望成为解决MSCs相关挑战的潜在方案，有可能作为传统药物疗法的替代方法。此外，iMSCs的产物，即诱导多能干细胞衍生的间充质干细胞衍生的细胞外囊泡（iMSC-EVs），可能表现出与iMSCs相似的功能。凭借细胞外囊泡的生物学优势，它们已成为“无细胞疗法”的焦点。在此，我们全面总结了iMSCs对免疫细胞的生物学影响，探讨了iMSCs和iMSC-EVs在疾病中的应用，并简要讨论了细胞外囊泡的基本特征。最后，我们概述了与iMSCs和iMSC-EVs相关的当前优势和挑战。我们希望这篇关于iMSCs和iMSC-EVs的综述将有助于开发治疗疾病的新方法。
