个体肌肉肥大反应受超负荷进展模型的影响，并与卫星细胞含量的变化相关。
Individual muscle hypertrophy response is affected by the overload progression model and is associated with changes in satellite cell content.
作者信息
Scarpelli Maíra C, Bergamasco João G A, Godwin Joshua S, Mesquita Paulo H C, Chaves Talisson S, Silva Deivid G, Bittencourt Diego, Dias Nathalia F, Junior Ricardo A Medalha, Filho Paulo C Carello, Angleri Vitor, Costa Luiz A R, Kavazis Andreas N, Ugrinowitsch Carlos, Roberts Michael D, Libardi Cleiton A
机构信息
MUSCULAB - Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education, Federal University of São Carlos - UFSCar, Rod. Washington Luiz, km 235 - SP 310, São Carlos, SP, CEP 13565-905, Brazil.
School of Kinesiology, Nutrabolt Applied and Molecular Sciences Laboratory, Auburn University, 301 Wire Road, Office 286, Auburn, AL, 36849, USA.
出版信息
Eur J Appl Physiol. 2025 Jun 11. doi: 10.1007/s00421-025-05817-y.
PURPOSE
We aimed to compare individual hypertrophic responses to resistance training in which overload progressed either by adjusting the load (LOADProg) or by increasing the number of repetitions (REPSProg). Furthermore, we investigated whether greater responsiveness to one protocol was associated with chronic changes in myonuclei and satellite cells, proteolysis and extracellular matrix (ECM) remodeling biomarkers.
METHODS
Thirty-seven untrained participants had their legs randomized into LOADProg and REPSProg and underwent 10 weeks of training. Muscle cross-sectional area (mCSA) ultrasound and muscle biopsies were performed pre- and post-training. Based on mCSA changes between protocols, we applied a criterion of 2 typical errors (5.7%) to create 4 clusters.
RESULTS
Twelve participants (~ 34%) showed greater mCSA increases after REPSProg (14.2 ± 7.6%) than LOADProg (3.4 ± 8.7%, p = 0.004). Seven participants (~ 19%) responded better to LOADProg (21.5 ± 7.5% vs. 12 ± 7.5%, p = 0.041). Thirteen participants (~ 35%) showed no differences between protocols (p = 0.852). Five participants were nonresponders (mCSA changes smaller than the 5.7% threshold) for both protocols. There were no significant differences (p > 0.05) in myonuclear content, proteolysis, or ECM remodeling markers within any of the clusters. However, for those who responded better to REPSProg, this protocol promoted greater satellite cell changes (108.6 ± 77.0%) than LOADProg (48.9 ± 63.1%, p = 0.015).
CONCLUSION
Our findings suggest that overload progression models may influence individual responsiveness to RT-induced muscle hypertrophy. Additionally, progression through increased repetitions was associated with a chronic addition of satellite cells. However, responsiveness was not explained by chronic changes in myonuclei, proteolysis or ECM remodeling biomarkers.
TRIAL REGISTRATION
This study is registered in the Brazilian Registry of Clinical Trials (RBR-57v9mrb).
目的
我们旨在比较个体对阻力训练的肥大反应，其中负荷通过调整重量（LOADProg）或增加重复次数（REPSProg）来递增。此外，我们研究了对一种训练方案的更大反应性是否与肌核和卫星细胞的慢性变化、蛋白水解和细胞外基质（ECM）重塑生物标志物有关。
方法
37名未经训练的参与者将其双腿随机分为LOADProg组和REPSProg组，并进行10周的训练。在训练前后进行肌肉横截面积（mCSA）超声检查和肌肉活检。根据训练方案之间的mCSA变化，我们应用2个典型误差（5.7%）的标准创建4个聚类。
结果
12名参与者（约34%）在REPSProg训练后mCSA增加幅度（14.2±7.6%）大于LOADProg训练后（3.4±8.7%，p = 0.004）。7名参与者（约19%）对LOADProg反应更好（21.5±7.5%对12±7.5%，p = 0.041）。13名参与者（约35%）在两种训练方案之间没有差异（p = 0.852）。5名参与者对两种训练方案均无反应（mCSA变化小于5.7%阈值）。在任何聚类中，肌核含量、蛋白水解或ECM重塑标志物均无显著差异（p>0.05）。然而，对于那些对REPSProg反应更好的人，该训练方案比LOADProg促进了更大的卫星细胞变化（108.6±77.0%对48.9±63.1%，p = 0.015）。
结论
我们的研究结果表明，负荷递增模型可能会影响个体对阻力训练诱导的肌肉肥大的反应性。此外，通过增加重复次数进行递增与卫星细胞的慢性增加有关。然而，反应性不能通过肌核、蛋白水解或ECM重塑生物标志物的慢性变化来解释。
试验注册
本研究已在巴西临床试验注册中心注册（RBR-57v9mrb）。
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