Wu Wei, Wu Zijuan, Xia Yi, Qin Shuchao, Li Yue, Wu Jiazhu, Liang Jinhua, Wang Li, Zhu Huayuan, Fan Lei, Fu Jianxin, Xu Wei, Jin Hui, Li Jianyong
Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.
Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, China.
Aging (Albany NY). 2019 Jun 1;11(11):3561-3573. doi: 10.18632/aging.101997.
Circular RNAs (circRNAs) have recently been reported to play crucial roles in various regulatory processes and involved in cancer onset and progression. However, the potential mechanism of circRNAs in chronic lymphocytic leukemia (CLL) remains largely unknown. Here, we observed hsa_circ_0132266 (circ_0132266), a circRNA significantly decreased in the peripheral blood mononuclear cells (PBMCs) of CLL patients compared with healthy donors, could act as an endogenous sponge of hsa-miR-337-3p (miR-337-3p) and regulate its activity, which resulted in a downstream change of target-gene PML and a consequent influence on cell viability. Taken together, our data indicated the regulatory mechanism of circ_0132266 in CLL progression through circ_0132266/miR-337-3p/PML axis, suggesting that it may serve as a biomarker as well as an exploitable therapeutic target for CLL.
环状RNA（circRNAs）最近被报道在各种调控过程中发挥关键作用，并参与癌症的发生和发展。然而，circRNAs在慢性淋巴细胞白血病（CLL）中的潜在机制仍 largely未知。在此，我们观察到hsa_circ_0132266（circ_0132266），一种在CLL患者外周血单个核细胞（PBMCs）中与健康供体相比显著降低的circRNA，可作为hsa-miR-337-3p（miR-337-3p）的内源性海绵并调节其活性，这导致靶基因PML的下游变化并进而影响细胞活力。综上所述，我们的数据表明circ_0132266通过circ_0132266/miR-337-3p/PML轴在CLL进展中的调控机制，表明它可能作为CLL的生物标志物以及可开发的治疗靶点。
