Department of Emergency Medicine, School of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, 310003, People's Republic of China.
Zhejiang Key Laboratory for Diagnosis and Treatment of Physic-Chemical and Aging-Related Injuries, Hangzhou, Zhejiang, 310003, People's Republic of China.
Cell Biol Toxicol. 2024 Aug 13;40(1):70. doi: 10.1007/s10565-024-09911-3.
Paraquat poisoning results in significant pulmonary damage, but current treatments are only minimally effective in repairing the injured lung tissues. Recent research has highlighted the promise of using stem cell therapy, namely mesenchymal stem cells, as a new method for treating paraquat toxicity. These cells have shown effectiveness in decreasing inflammation, apoptosis, and fibrosis in the mice lungs subjected to paraquat. The therapeutic implications of mesenchymal stem cells are believed to arise from their release of bioactive proteins and their capacity to regulate inflammatory responses. However, additional clinical study is required to validate these therapies' efficacy. This review thoroughly explores the pathophysiology of paraquat poisoning and the properties of mesenchymal stem cells. Additionally, it critically assesses the long-term safety and effectiveness of mesenchymal stem cell therapies, which is crucial for developing more dependable and effective treatment protocols. In summary, although mesenchymal stem cells offer promising prospects for treating lung injuries, more investigations are required to optimize their therapeutic promise and ensure their safe clinical application in the context of paraquat poisoning.
百草枯中毒会导致严重的肺部损伤，但目前的治疗方法在修复受损的肺组织方面效果甚微。最近的研究强调了使用干细胞疗法，即间充质干细胞，作为治疗百草枯毒性的新方法的前景。这些细胞已被证明能有效减少百草枯引起的小鼠肺部炎症、细胞凋亡和纤维化。间充质干细胞的治疗意义可能源于其释放的生物活性蛋白和调节炎症反应的能力。然而，需要更多的临床研究来验证这些疗法的疗效。本综述深入探讨了百草枯中毒的病理生理学和间充质干细胞的特性。此外，还对间充质干细胞疗法的长期安全性和有效性进行了批判性评估，这对于制定更可靠、更有效的治疗方案至关重要。总之，尽管间充质干细胞为治疗肺损伤提供了有希望的前景，但仍需要进一步研究来优化其治疗潜力，并确保其在百草枯中毒的临床应用中的安全性。
