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巨噬细胞衍生的外泌体作为炎症的先进治疗方法：当前进展和未来展望。

Macrophage-Derived Exosomes as Advanced Therapeutics for Inflammation: Current Progress and Future Perspectives.

机构信息

Graduate School, Wuhan Sports University, Wuhan, Hubei Province, People's Republic of China.

Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei Province, People's Republic of China.

出版信息

Int J Nanomedicine. 2024 Feb 19;19:1597-1627. doi: 10.2147/IJN.S449388. eCollection 2024.

DOI:10.2147/IJN.S449388
PMID:38406601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10888065/
Abstract

The development of numerous diseases is significantly influenced by inflammation. Macrophage-derived exosomes (M-Exos) play a role in controlling inflammatory reactions in various conditions, including chronic inflammatory pain, hypertension, and diabetes. However, the specific targets and roles of M-Exos in regulating inflammation in diseases remain largely unknown. This review summarizes current knowledge on M-Exos biogenesis and provides updated information on M-Exos' biological function in inflammation modulation. Furthermore, this review highlights the functionalization and engineering strategies of M-Exos, while providing an overview of cutting-edge approaches to engineering M-Exos and advancements in their application as therapeutics for inflammation modulation. Finally, multiple engineering strategies and mechanisms are presented in this review along with their perspectives and challenges, and the potential contribution that M-Exos may have in diseases through the modulation of inflammation is discussed.

摘要

许多疾病的发展都受到炎症的显著影响。巨噬细胞衍生的外泌体（M-Exos）在控制各种情况下的炎症反应中发挥作用，包括慢性炎性疼痛、高血压和糖尿病。然而，M-Exos 在调节疾病中的炎症的具体靶点和作用仍很大程度上未知。本综述总结了 M-Exos 生物发生的最新知识，并提供了 M-Exos 在炎症调节中的生物学功能的最新信息。此外，本综述强调了 M-Exos 的功能化和工程化策略，同时概述了工程化 M-Exos 的前沿方法及其作为炎症调节治疗剂的应用进展。最后，本综述提出了多种工程化策略和机制及其观点和挑战，并讨论了 M-Exos 通过调节炎症可能对疾病做出的潜在贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7196/10888065/8438a686247b/IJN-19-1597-g0007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7196/10888065/8a8d6b416dde/IJN-19-1597-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7196/10888065/b5295cee564c/IJN-19-1597-g0006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7196/10888065/fb6d208f2df0/IJN-19-1597-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7196/10888065/0dbd03e447e9/IJN-19-1597-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7196/10888065/82e867e65c4f/IJN-19-1597-g0003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7196/10888065/8a8d6b416dde/IJN-19-1597-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7196/10888065/b5295cee564c/IJN-19-1597-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7196/10888065/8438a686247b/IJN-19-1597-g0007.jpg

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