肥胖可能是由于棕色脂肪功能失调所致。
Obesity may be due to a malfunctioning of brown fat.
作者信息
Himms-Hagen J
出版信息
Can Med Assoc J. 1979 Nov 17;121(10):1361-4.
Abstract
Recent basic research on the functioning of brown fat, a heat-producing tissue, has been fitted together with research on obesity to provide an exciting and challenging new approach to the study of the cause of obesity and could serve as a starting point for the development of new modes of treatment. Recent studies on brown adipose tissue have shown that a defect in this tissue is one probable cause of obesity.
摘要
近期关于褐色脂肪（一种产热组织）功能的基础研究，已与肥胖研究相结合，为肥胖成因的研究提供了一种令人兴奋且具有挑战性的新方法，并可能成为开发新治疗模式的起点。近期对褐色脂肪组织的研究表明，该组织的缺陷是肥胖的一个可能原因。
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本文引用的文献
1
Brown adipose tissue and heat production in the newborn infant.新生儿的棕色脂肪组织与产热
J Pathol Bacteriol. 1966 Jan;91(1):223-34. doi: 10.1002/path.1700910126.
2
The distribution of brown adipose tissue in the human.人体中棕色脂肪组织的分布。
J Anat. 1972 May;112(Pt 1):35-9.
3
Growth and distribution of human fetal brown fat.
Anat Rec. 1974 Mar;178(3):637-45. doi: 10.1002/ar.1091780311.
4
Increased thermal body insulation: relationship to the development of obesity.
J Appl Physiol. 1974 Jun;36(6):674-8. doi: 10.1152/jappl.1974.36.6.674.
5
The influence of obesity on health (first of two parts).
N Engl J Med. 1974 Jul 25;291(4):178-85. doi: 10.1056/NEJM197407252910405.
6
Binding of guanine nucleotides to the outer surface of the inner membrane of guinea pig brown fat mitochondria in correlation with the thermogenic activity of the tissue.
FEBS Lett. 1976 Apr 1;63(2):304-8. doi: 10.1016/0014-5793(76)80117-2.
7
Hamster brown-adipose-tissue mitochondria. Purine nucleotide control of the ion conductance of the inner membrane, the nature of the nucleotide binding site.仓鼠棕色脂肪组织线粒体。嘌呤核苷酸对内膜离子电导的控制，核苷酸结合位点的性质。
Eur J Biochem. 1976 Feb 16;62(2):223-8. doi: 10.1111/j.1432-1033.1976.tb10151.x.
8
The occurrence of brown adipose tissue in perirenal fat in Japanese.
Arch Histol Jpn. 1975 Jun;38(1):43-70. doi: 10.1679/aohc1950.38.43.
9
Mitochondrial protein alteration in active brown fat: a soidum dodecyl sulfate-polyacrylamide gel electrophoretic study.活跃棕色脂肪中的线粒体蛋白改变：一项十二烷基硫酸钠-聚丙烯酰胺凝胶电泳研究。
Biochem Biophys Res Commun. 1976 Dec 6;73(3):577-83. doi: 10.1016/0006-291x(76)90849-4.
10
Possible function of human brown adipose tissue as suggested by observation on perirenal brown fats from necropsy cases of variable age groups.
Arch Histol Jpn. 1976 May;39(2):117-45. doi: 10.1679/aohc1950.39.117.
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