Cellulose and Paper Department, National Research Centre, 33 El Bohouth Str., P.O. 12622, Dokki, Giza, Egypt.
Nutrition and Food Science Department, Research of food Industries and Nutrition Institute, National Research Centre, 33 El Bohouth St. (former El Tahrir St.), P.O. 12622, Dokki, Cairo, Egypt.
BMC Pharmacol Toxicol. 2024 Aug 13;25(1):50. doi: 10.1186/s40360-024-00768-0.
This study reports a novel, eco-friendly; fast and cost-effective microwave method for synthesizing carboxymethylated graphene oxide (CMGO) from sugarcane residues. Fourier-transform infrared spectroscopy (FTIR) confirmed successful CMGO synthesis through the presence of characteristic peaks at 1567.93 and 1639.29 cm (COONa vibrations) and increased CH intensity compared to unmodified graphene oxide (GO). Furthermore, CMGO derived from sugarcane residues demonstrated potential in mitigating the side effects of toxic materials like carbon tetrachloride (CCl). Treatment with CMGO partially reduced elevated levels of liver enzymes (ALT and AST) and nitrogenous waste products (urea and uric acid) in CCl-induced liver damage models, suggesting an improvement in liver function despite ongoing cellular damage.This work paves the way for a sustainable and economical approach to produce functionalized graphene oxide with promising biomedical applications in alleviating toxin-induced liver injury.
本研究报告了一种新颖、环保、快速且经济高效的微波法，从甘蔗渣中合成羧甲基化氧化石墨烯（CMGO）。傅里叶变换红外光谱（FTIR）证实了 CMGO 的成功合成，特征峰出现在 1567.93 和 1639.29 cm（COONa 振动）处，与未改性氧化石墨烯（GO）相比，CH 强度增加。此外，甘蔗渣衍生的 CMGO 显示出减轻有毒物质如四氯化碳（CCl）的副作用的潜力。用 CMGO 处理部分降低了 CCl 诱导的肝损伤模型中升高的肝酶（ALT 和 AST）和含氮废物（尿素和尿酸）水平，表明尽管存在持续的细胞损伤，但肝功能有所改善。这项工作为生产具有功能化氧化石墨烯的可持续和经济方法铺平了道路，有望在减轻毒素诱导的肝损伤方面有应用前景。
