Rydz E, Walld R, Quinn E K, Koehoorn M W, McLeod C B, Demers P A, Peters C E, Kraut A
CAREX Canada, University of British Columbia, Vancouver, British Columbia, Canada.
Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Contact Dermatitis. 2024 Nov;91(5):412-423. doi: 10.1111/cod.14674. Epub 2024 Aug 13.
This exploratory study aimed to assess contact dermatitis (CD) risk among workers using the Manitoba Occupational Disease Surveillance System (MODSS).
The MODSS linked accepted time-loss claims from the Workers' Compensation Board of Manitoba (2006-2019), with administrative health data from medical and hospital records (1996-2020). CD risk by occupation and industry (hazard ratio, 95% confidence intervals) was estimated using Cox proportional hazard models, adjusted for age and stratified by sex.
Increased risk of new onset CD was observed among some occupations and industries with known skin irritants and allergens. Some occupations with known increased risks of CD remained elevated when removing the accepted WCB cases was performed, suggesting that all CD cases in these occupations may not show up in WCB statistics. Increased risk was also observed for occupations and industries with unknown exposures related to CD, whereas some groups known to be at risk of CD were not observed to have elevated risks in this cohort.
The MODSS successfully identified some occupations and industries known to be at high risk of occupational CD, but not others. Some occupations not typically associated with work-related CD were also identified, which warrants further investigation.
本探索性研究旨在利用曼尼托巴省职业病监测系统（MODSS）评估工人接触性皮炎（CD）的风险。
MODSS将曼尼托巴省工人赔偿委员会（2006 - 2019年）受理的误工索赔与医疗和医院记录中的行政健康数据（1996 - 2020年）相链接。使用Cox比例风险模型估计按职业和行业划分的CD风险（风险比，95%置信区间），并对年龄进行调整，按性别分层。
在一些存在已知皮肤刺激物和过敏原的职业和行业中，观察到新发CD风险增加。在排除已受理的工人赔偿委员会病例后，一些已知CD风险增加的职业风险仍然较高，这表明这些职业中的所有CD病例可能并未在工人赔偿委员会的统计数据中体现出来。在与CD相关暴露情况不明的职业和行业中也观察到风险增加，而在该队列中，一些已知有CD风险的群体并未观察到风险升高。
MODSS成功识别出一些已知职业性CD高风险的职业和行业，但未识别出其他一些。还识别出一些通常与工作相关CD无关的职业，这值得进一步调查。
