Xie Zi-Feng, Wang Sheng-Yu, Gao Yuan, Zhang Yi-Dan, Han Ya-Nan, Huang Jin, Gao Mei-Na, Wang Chun-Guang
Department of Anesthesiology, The First Central Hospital of Baoding, Northern Great Wall Street 320#, Baoding, 071000, Hebei, China.
Department of Anesthesiology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121000, Liaoning, China.
Mol Cell Biochem. 2025 Mar;480(3):1343-1357. doi: 10.1007/s11010-024-05091-0. Epub 2024 Aug 13.
Postoperative cognitive dysfunction (POCD) impacts a significant number of patients annually, frequently impairing their cognitive abilities and resulting in unfavorable clinical outcomes. Aimed at addressing cognitive impairment, vagus nerve stimulation (VNS) is a therapeutic approach, which was used in many mental disordered diseases, through the modulation of vagus nerve activity. In POCD model, the enhancement of cognition function provided by VNS was shown, demonstrating VNS effect on cognition in POCD. In the present study, we primarily concentrates on elucidating the role of the VNS improving the cognitive function in POCD, via two potential mechanisms: the inflammatory microenvironment and epigenetics. This study provided a theoretical support for the feasibility that VNS can be a potential method to enhance cognition function in POCD.
术后认知功能障碍（POCD）每年影响大量患者，常常损害他们的认知能力并导致不良的临床结果。旨在解决认知障碍的迷走神经刺激（VNS）是一种治疗方法，它通过调节迷走神经活动被用于许多精神障碍性疾病。在POCD模型中，已显示VNS可增强认知功能，证明了VNS对POCD认知功能的影响。在本研究中，我们主要致力于通过两种潜在机制——炎症微环境和表观遗传学，来阐明VNS改善POCD认知功能的作用。本研究为VNS可成为增强POCD认知功能的潜在方法的可行性提供了理论支持。
