Cordingley Dean M, Taheri Maryam, Fasihiyan Moein, Woodmass Jarret M, Cornish Stephen M
Applied Health Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Pan Am Clinic Foundation, 75 Poseidon Bay, Winnipeg, MB R3M 3E4, Canada.
Nutrients. 2025 Apr 5;17(7):1273. doi: 10.3390/nu17071273.
: Orthopedic surgery and the corresponding events (i.e., immobilization and muscle disuse) result in a cascade of biological events to promote healing but can come with the loss of skeletal muscle mass and strength. A good nutritional status of patients is associated with positive post-surgical outcomes, with macronutrients receiving the majority of emphasis in the research literature. However, beyond the surgical literature, there are other nutrients and nutritional supplements that have been established or postulated to improve skeletal muscle mass and strength. : The purpose of this narrative review is to provide evidence for the utility of using creatine, vitamin D, omega-3 fatty acids, glutamine, essential amino acids-branched chain amino acids (EAA-BCAA) and beta-hydroxy-beta-methylbutyrate (HMB) supplementation and the role they may play in minimizing muscle atrophy and strength loss following orthopedic surgery. The review will also highlight areas of future research to support a better understanding of the efficacy of supplementing with these substances pre- and/or post-surgery.
骨科手术以及相应的情况（即固定和肌肉废用）会引发一系列生物学事件以促进愈合，但同时可能导致骨骼肌质量和力量的丧失。患者良好的营养状况与积极的术后结果相关，在研究文献中，宏量营养素受到了大部分关注。然而，除了外科手术文献之外，还有其他营养素和营养补充剂已被证实或推测可以改善骨骼肌质量和力量。：本叙述性综述的目的是为使用肌酸、维生素D、ω-3脂肪酸、谷氨酰胺、必需氨基酸 - 支链氨基酸（EAA - BCAA）和β-羟基-β-甲基丁酸酯（HMB）补充剂的效用提供证据，以及它们在最小化骨科手术后肌肉萎缩和力量丧失方面可能发挥的作用。该综述还将强调未来的研究领域，以支持更好地理解在手术前和/或手术后补充这些物质的功效。
