中性粒细胞与淋巴细胞比值（NLR）在卵巢癌中的预后及临床价值：一项系统评价和荟萃分析

The prognostic and clinical value of neutrophil-to-lymphocyte ratio (NLR) in ovarian cancer: A systematic review and meta-analysis.

作者信息

Zhang Zihan, Lang Jinghe

机构信息

Chinese Academy of Medical Sciences, Union Medical College, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, China.

出版信息

J Med Biochem. 2024 Jun 15;43(4):323-333. doi: 10.5937/jomb0-46035.

BACKGROUND

Ovarian cancer (OC) is a major gynecological malignancy with varying prognosis. The Neutrophil-toLymphocyte Ratio (NLR) has been proposed as a potential prognostic biomarker. This study aimed to evaluate the prognostic and clinical value of NLR in OC.

METHODS

A systematic review and meta-analysis were performed following PRISMA guidelines, including studies that evaluated the association between NLR and survival outcomes in OC patients. Search was performed in PubMed, Embase, Web of Science, and Cochrane Library databases. Quality assessment was done using Newcastle-Ottawa Scale (NOS). Heterogeneity was assessed, and pooled hazard ratios (HRs) were calculated using fixed or random-effects models as appropriate.