Zhou Mingyi, Li Liankun, Wang Xiaobin, Wang Chunyan, Wang Danbo
Cell Physiol Biochem. 2018;46(1):178-186. doi: 10.1159/000488420. Epub 2018 Mar 21.
BACKGROUND/AIMS: Prognostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet count (PC) in patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIIC epithelial ovarian cancer (EOC) is controversial.
A total of 370 stage IIIC EOC patients who underwent primary debulking surgery (PDS) at the Department of Gynecology of Liaoning Cancer Hospital and Institute between January 2003 and August 2016 and had full information were involved. Patients were stratified into a high NLR (H-NLR) group versus a low NLR (L-NLR) group and a high PC (H-PC) group versus a low PC (L-PC) group according to cutoff values calculated through receiver operating characteristic (ROC) curves. Prognostic values of NLR and PC for progression-free survival (PFS) and overall survival (OS) were assessed.
We identified the optimal cut-off value of 3.08 for NLR and 289.5*109/L for PC. The median PFS and OS of the patients with H-NLR were shorter than L-NLR (PFS: 16.9 months vs. 19.5 months, hazard ratio [HR] 1.3, 95% confidence interval [CI] 1.03-1.63, P = 0.022; OS: 33.5 months vs. 46.8 months, HR 1.3, 95% CI 1.01-1.66, P = 0.001). The median PFS and OS of the patients with H-PC were shorter than L-PC (PFS: 15.3 months vs. 21.6 months, HR 1.3, 95% CI 1.04-1.63, P < 0.001; OS: 37.3 months vs. 46.1 months, HR 1.14, 95% CI 0.89-1.46, P = 0.306).
H-NLR and H-PC could predict poor long-term outcome of patients with FIGO stage III EOC.
背景/目的：中性粒细胞与淋巴细胞比值（NLR）和血小板计数（PC）在国际妇产科联盟（FIGO）IIIC期上皮性卵巢癌（EOC）患者中的预后价值存在争议。
纳入2003年1月至2016年8月期间在辽宁省肿瘤医院妇科接受初次肿瘤细胞减灭术（PDS）且资料完整的370例IIIC期EOC患者。根据通过受试者工作特征（ROC）曲线计算出的临界值，将患者分为高NLR（H-NLR）组与低NLR（L-NLR）组以及高PC（H-PC）组与低PC（L-PC）组。评估NLR和PC对无进展生存期（PFS）和总生存期（OS）的预后价值。
我们确定NLR的最佳临界值为3.08，PC的最佳临界值为289.5×10⁹/L。H-NLR患者的中位PFS和OS短于L-NLR患者（PFS：16.9个月对19.5个月，风险比[HR]1.3，95%置信区间[CI]1.03 - 1.63，P = 0.022；OS：33.5个月对46.8个月，HR 1.3，95% CI 1.01 - 1.66，P = 0.001）。H-PC患者的中位PFS和OS短于L-PC患者（PFS：15.3个月对21.6个月，HR 1.3，95% CI 1.04 - 1.63，P < 0.001；OS：37.3个月对46.1个月，HR 1.14，95% CI 0.89 - 1.46，P = 0.306）。
高NLR和高PC可预测FIGO III期EOC患者的长期预后不良。
