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基于骨代谢生化指标的老年骨质疏松性骨折危险因素及预测效能分析

Analysis of risk factors and predictive efficacy of senile osteoporosis fracture based on biochemical indicators of bone metabolism.

作者信息

Mao Yufang, Li Kanghua, Zhu Bing, Long Jiang

机构信息

Zhuzhou Peopležs Hospital, Sports Medicine, Zhuzhou, China.

Zhuzhou Peopležs Hospital, Department of Rehabilitation Medicine, Zhuzhou, China.

出版信息

J Med Biochem. 2024 Jun 15;43(4):451-459. doi: 10.5937/jomb0-46663.

DOI:10.5937/jomb0-46663
PMID:39139178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11318057/
Abstract

A total of 254 elderly OS patients diagnosed and treated in our hospital during May 2019 to April 2022 was randomly picked, of which 100 patients were finally enrolled. Patients were divided into OS fracture group and non-fracture group according to whether they had OS fracture. The contents of bone mineral density (BMD) and bone metabolism biochemical indexes, including Dickkopf1 (DKK-1), sclerostin (SOST), osteoprotegerin (OPG), osteopontin (OPN), osteocalcin (BGP) and 25 hydroxyvitamin D (25 (OH) D) were detected in lumbar L2č4 and left femoral greater trochanter. The correlation between bone metabolism and BMD was evaluated using Pearson analysis. The risk factors of OS fracture were analyzed using Multivariate logistic regression analysis. The predictive value of biochemical indexes of bone metabolism on the risk of OS fracture was analyzed using ROC curve.

摘要

随机选取2019年5月至2022年4月期间在我院诊断并治疗的254例老年骨质疏松症（OS）患者，最终纳入100例患者。根据是否发生OS骨折，将患者分为OS骨折组和非骨折组。检测腰椎L2-4和左股骨大转子处的骨密度（BMD）及骨代谢生化指标，包括Dickkopf1（DKK-1）、硬化蛋白（SOST）、骨保护素（OPG）、骨桥蛋白（OPN）、骨钙素（BGP）和25羟维生素D（25(OH)D）的含量。采用Pearson分析评估骨代谢与BMD之间的相关性。采用多因素logistic回归分析OS骨折的危险因素。采用ROC曲线分析骨代谢生化指标对OS骨折风险的预测价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eec/11318057/05b9e71c90b9/jomb-43-3-2403451M_g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eec/11318057/8671ffe99d07/jomb-43-3-2403451M_g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eec/11318057/23c605ed2d3b/jomb-43-3-2403451M_g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eec/11318057/05b9e71c90b9/jomb-43-3-2403451M_g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eec/11318057/8671ffe99d07/jomb-43-3-2403451M_g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eec/11318057/23c605ed2d3b/jomb-43-3-2403451M_g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eec/11318057/05b9e71c90b9/jomb-43-3-2403451M_g003.jpg

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Update on Osteoporosis Screening and Management.骨质疏松症筛查和管理的最新进展。
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Bone Sclerostin and Dickkopf-related protein-1 are positively correlated with bone mineral density, bone microarchitecture, and bone strength in postmenopausal osteoporosis.
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