Affiliated Hospital of Stomatology, Medical College, Zhejiang University, Hangzhou, Zhejiang, China (mainland).
Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang University, Hangzhou, Zhejiang, China (mainland).
Med Sci Monit. 2020 Jan 30;26:e919159. doi: 10.12659/MSM.919159.
Osteopontin (OPN), a secreted phosphoprotein, is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of cell matrix proteins and participates in many biological activities. Studies have shown that OPN plays a role in bone metabolism and homeostasis. OPN not only is an important factor in neuron-mediated and endocrine-regulated bone mass, but also is involved in biological activities such as proliferation, migration, and adhesion of several bone-related cells, including bone marrow mesenchymal stem cells, hematopoietic stem cells, osteoclasts, and osteoblasts. OPN has been demonstrated to be closely related to the occurrence and development of many bone-related diseases, such as osteoporosis, rheumatoid arthritis, and osteosarcoma. As expected, the functions of OPN in the bone have become a research hotspot. In this article, we try to decipher the mechanism of OPN-regulated bone metabolism and bone diseases.
骨桥蛋白（OPN）是一种分泌型磷蛋白，属于细胞基质蛋白小整合素结合配体 N-连接糖蛋白（SIBLING）家族，参与多种生物学活动。研究表明，OPN 在骨代谢和动态平衡中发挥作用。OPN 不仅是神经元介导和内分泌调节骨量的重要因素，而且还参与包括骨髓间充质干细胞、造血干细胞、破骨细胞和成骨细胞在内的几种与骨相关的细胞的增殖、迁移和黏附等生物学活动。已经证实 OPN 与许多与骨相关的疾病（如骨质疏松症、类风湿关节炎和骨肉瘤）的发生和发展密切相关。因此，OPN 在骨中的功能已成为研究热点。本文试图解析 OPN 调节骨代谢和骨疾病的机制。
