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经纵隔原发性肺脂肪肉瘤:病例报告及治疗策略综述

Transmediastinal primary pulmonary liposarcoma: Case report and review of management strategies.

作者信息

Wilcox Taylor, Kleinertz Aaron, Seadler Benjamin D, Joyce Lyle D, Charlson John, Linsky Paul L

机构信息

Medical College of Wisconsin, Milwaukee, WI, USA.

Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.

出版信息

Rare Tumors. 2024 Aug 11;16:20363613241274230. doi: 10.1177/20363613241274230. eCollection 2024.

DOI:10.1177/20363613241274230
PMID:39139396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11320392/
Abstract

Soft tissue sarcomas account for less than 1% of new cancer diagnoses, approximately one in five of which are liposarcomas. These tumors typically arise in the deep tissues of the proximal extremity or retroperitoneum, with just under 3% presenting as primary intrathoracic neoplasms. We present an exceedingly rare and particularly unique presentation of primary lung liposarcoma which traversed the mediastinum into the contralateral hemithorax. This report highlights the primary characteristics of the disease and underscores the importance of a multidisciplinary approach to its successful treatment.

摘要

软组织肉瘤占新诊断癌症的比例不到1%,其中约五分之一为脂肪肉瘤。这些肿瘤通常发生在近端肢体或腹膜后的深部组织,原发性胸内肿瘤的发生率略低于3%。我们报告了一例极为罕见且特别独特的原发性肺脂肪肉瘤病例,该肿瘤穿过纵隔进入对侧半胸。本报告强调了该疾病的主要特征,并强调了多学科方法对其成功治疗的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11320392/22289d413d37/10.1177_20363613241274230-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11320392/25cfdd85c1ef/10.1177_20363613241274230-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11320392/89880433256c/10.1177_20363613241274230-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11320392/22289d413d37/10.1177_20363613241274230-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11320392/25cfdd85c1ef/10.1177_20363613241274230-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11320392/89880433256c/10.1177_20363613241274230-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11320392/22289d413d37/10.1177_20363613241274230-fig3.jpg

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本文引用的文献

1
Clinicopathological Features of Intrathoracic Liposarcoma-A Systematic Review with an Illustrative Case.胸内脂肪肉瘤的临床病理特征——附病例说明的系统评价
J Clin Med. 2022 Dec 10;11(24):7353. doi: 10.3390/jcm11247353.
2
Giant pulmonary pleomorphic liposarcoma: A case report and literature review.巨大型肺多形性脂肪肉瘤:一例报告及文献复习
Asian J Surg. 2023 Feb;46(2):1109-1110. doi: 10.1016/j.asjsur.2022.07.137. Epub 2022 Aug 10.
3
Preoperative Radiotherapy in Patients With Primary Retroperitoneal Sarcoma: EORTC-62092 Trial (STRASS) Versus Off-trial (STREXIT) Results.
原发性腹膜后肉瘤患者的术前放疗:EORTC-62092 试验(STRASS)与非试验(STREXIT)结果。
Ann Surg. 2023 Jul 1;278(1):127-134. doi: 10.1097/SLA.0000000000005492. Epub 2022 Jul 14.
4
A successful trimodality therapy for difficult-to-diagnose primary mediastinal dedifferentiated liposarcoma, which originated from the perihilar fat and invaded the right lungs.成功采用三联疗法治疗起源于肺门周围脂肪并侵犯右肺的难以诊断的原发性纵隔去分化脂肪肉瘤。
Gen Thorac Cardiovasc Surg. 2022 Mar;70(3):298-302. doi: 10.1007/s11748-021-01735-w. Epub 2021 Nov 16.
5
The 2020 WHO Classification of Tumors of Soft Tissue: Selected Changes and New Entities.《2020 年世卫组织软组织肿瘤分类:精选变更和新实体》。
Adv Anat Pathol. 2021 Jan;28(1):44-58. doi: 10.1097/PAP.0000000000000284.
6
Preoperative radiotherapy plus surgery versus surgery alone for patients with primary retroperitoneal sarcoma (EORTC-62092: STRASS): a multicentre, open-label, randomised, phase 3 trial.术前放疗加手术与单纯手术治疗原发性腹膜后肉瘤患者(EORTC-62092:STRASS):一项多中心、开放标签、随机、III 期临床试验。
Lancet Oncol. 2020 Oct;21(10):1366-1377. doi: 10.1016/S1470-2045(20)30446-0. Epub 2020 Sep 14.
7
Dedifferentiated Liposarcoma: Systemic Therapy Options.去分化脂肪肉瘤:系统治疗选择。
Curr Treat Options Oncol. 2020 Feb 5;21(2):15. doi: 10.1007/s11864-020-0705-7.
8
Treatment Facility: An Important Prognostic Factor for Dedifferentiated Liposarcoma Survival.治疗机构:去分化脂肪肉瘤生存的一个重要预后因素。
Fed Pract. 2019 Aug;36(Suppl 5):S34-S41.
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Cancer Commun (Lond). 2019 Apr 2;39(1):15. doi: 10.1186/s40880-019-0358-8.
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