Meletaki Vasiliki, Gobinet Maélis, Léonard Jacques, Elzière Maya, Lopez Christophe
Aix Marseille Univ, CNRS, Centre de Recherche en Psychologie et Neurosciences (CRPN), Marseille, France.
Centre des Vertiges, European Hospital, Marseille, France.
Front Neurol. 2024 Jul 30;15:1388805. doi: 10.3389/fneur.2024.1388805. eCollection 2024.
Persistent Postural-Perceptual Dizziness (PPPD) is a functional vestibular condition. Despite being the most common chronic neuro-otologic disorder, it remains undertreated. The Niigata PPPD Questionnaire (NPQ), developed by Yagi et al. in 2019 to assess the severity of PPPD, could be a useful tool to help in the screening and diagnosis of this condition. This study aimed to validate a French version of the NPQ and make it an available assessment tool. Moreover, we aimed to understand the characteristics of PPPD patients better. The NPQ was translated and adapted into French. 50 PPPD patients, 50 patients with vestibular disorders without PPPD, and 50 healthy controls were included. They answered the adapted NPQ and additional questionnaires assessing trait (STAI) and state anxiety (HADS-A), depression (HADS-D) and handicap related to dizziness (DHI). The NPQ's reliability was assessed by Cronbach's alpha. Intergroup comparisons and multiple linear regressions were conducted to examine the characteristics of PPPD patients compared to vestibular patients and healthy controls, to validate NPQ's reliability, and to explore the effect of clinical parameters and treatment with selective serotonin reuptake inhibitors. Receiver operating characteristic (ROC) curves were carried out to determine the diagnostic values of the NPQ total score and sub-scores. Relations between NPQ and reported handicap, depression and anxiety were evaluated by correlations between questionnaire scores. The internal consistency was high (>0.8) for all NPQ subscales and the total score. Intergroup comparisons showed a significantly higher NPQ total score and sub-scores in the PPPD group compared to the two others. The ROC curve analysis showed a significant, but poor, discrimination of NPQ (AUC = 0.664) and its subscales. DHI scores, depressive symptoms and trait anxiety were significantly higher in PPPD patients than in vestibular patients and healthy controls. State anxiety did not differ between patients with PPPD and vestibular patients without PPPD. Finally, there was a significant correlation between the NPQ and the DHI. Our study provides a better understanding of PPPD symptomatology and its assessment. It showed that the NPQ is a reliable tool that can assist in symptom assessment for a French-speaking population.
持续性姿势-知觉性头晕（PPPD）是一种功能性前庭疾病。尽管它是最常见的慢性神经耳科疾病，但仍未得到充分治疗。八木等人在2019年开发的新潟PPPD问卷（NPQ）用于评估PPPD的严重程度，可能是有助于筛查和诊断这种疾病的有用工具。本研究旨在验证NPQ的法语版本并使其成为可用的评估工具。此外，我们旨在更好地了解PPPD患者的特征。NPQ被翻译并改编成法语。纳入了50名PPPD患者、50名无PPPD的前庭疾病患者和50名健康对照者。他们回答了改编后的NPQ以及评估特质（状态-特质焦虑量表，STAI）和状态焦虑（医院焦虑抑郁量表-焦虑分量表，HADS-A）、抑郁（医院焦虑抑郁量表-抑郁分量表，HADS-D）以及与头晕相关的残疾（头晕残障量表，DHI）的附加问卷。通过克朗巴哈系数评估NPQ的信度。进行组间比较和多元线性回归，以检查PPPD患者与前庭疾病患者和健康对照者相比的特征，验证NPQ的信度，并探索临床参数和选择性5-羟色胺再摄取抑制剂治疗的效果。绘制受试者工作特征（ROC）曲线以确定NPQ总分和各子量表的诊断价值。通过问卷得分之间的相关性评估NPQ与报告的残疾、抑郁和焦虑之间的关系。所有NPQ子量表和总分的内部一致性都很高（>0.8）。组间比较显示，与其他两组相比，PPPD组的NPQ总分和各子量表得分显著更高。ROC曲线分析显示NPQ及其子量表有显著但较差的区分度（曲线下面积，AUC = 0.664）。PPPD患者的DHI得分、抑郁症状和特质焦虑显著高于前庭疾病患者和健康对照者。PPPD患者与无PPPD的前庭疾病患者之间的状态焦虑没有差异。最后，NPQ与DHI之间存在显著相关性。我们的研究有助于更好地理解PPPD的症状学及其评估。研究表明，NPQ是一种可靠的工具，可协助对讲法语人群进行症状评估。
