Du Jia, Xiao Miao, Sudo Naomi, Liu Qinghua
College of Materials and Environmental Engineering Hangzhou Dianzi University Hangzhou China.
Suzhou Health-originated Bio-technology, Ltd. Suzhou China.
Food Sci Nutr. 2024 Apr 23;12(8):5271-5284. doi: 10.1002/fsn3.4183. eCollection 2024 Aug.
Cardiovascular diseases (CVDs) affect the quality of life or are fatal in the worst cases, resulting in a significant economic and social burden. Therefore, there is an urgent need to invent functional products or drugs for improving patient health and alleviating and controlling these diseases. Marine bioactive peptides reduce and control CVDs. Many of the predisposing factors triggering CVDs can be alleviated by consuming functional foods containing marine biopeptides. Therefore, improving CVD incidence through the use of effective biopeptide foods from marine sources has attracted increasing interest and attention. This review reports information on bioactive peptides derived from various marine organisms, focusing on the process of the separation, purification, and identification of biological peptides, biological characteristics, and functional food for promoting cardiovascular health. Increasing evidence shows that the bioactivity and safety of marine peptides significantly impact their storage, purification, and processing. It is feasible to develop further strategies involving functional foods to treat CVDs through effective safety testing methods. Future work should focus on producing high-quality marine peptides and applying them in the food and drug industry.
心血管疾病(CVDs)会影响生活质量,在最严重的情况下会导致死亡,从而造成巨大的经济和社会负担。因此,迫切需要发明功能性产品或药物来改善患者健康状况并减轻和控制这些疾病。海洋生物活性肽可减轻和控制心血管疾病。食用含有海洋生物肽的功能性食品可以缓解许多引发心血管疾病的诱发因素。因此,通过使用来自海洋来源的有效生物肽食品来降低心血管疾病发病率已引起越来越多的关注。本综述报告了来自各种海洋生物的生物活性肽的信息,重点关注生物肽的分离、纯化和鉴定过程、生物学特性以及促进心血管健康的功能性食品。越来越多的证据表明,海洋肽的生物活性和安全性对其储存、纯化和加工有重大影响。通过有效的安全测试方法制定涉及功能性食品治疗心血管疾病的进一步策略是可行的。未来的工作应集中在生产高质量的海洋肽并将其应用于食品和制药行业。