Pourhakim Rasul, Emadi Fatemeh, Razavi Dizaji Saeed, Talei Daryush, Esmaeili Saber Sayed Saeed, Iranzadasl Maryam
Department of Traditional Medicine, School of Persian Medicine Shahed University Tehran Iran.
Traditional Medicine Clinical Trial Research Center Shahed University Tehran Iran.
Food Sci Nutr. 2024 May 6;12(8):5473-5479. doi: 10.1002/fsn3.4185. eCollection 2024 Aug.
Globally, iron deficiency reigns as the most prevalent nutritional disorder, with anemia disproportionately impacting women of childbearing age. Despite the effectiveness of existing treatments, like iron supplements, their side effects remain a concern. This study explores the potential of grape syrup (GS), a functional iron-rich food, to modulate markers of iron-deficient anemia in women. A randomized, double-blind study explored the impact of GS on iron deficiency anemia markers in 130 women. Participants were allocated to intervention or placebo groups. For 4 weeks, the intervention group received a daily 50 mg ferrous sulfate tablet alongside 10 cc of GS thrice daily. The placebo group received a 50 mg ferrous sulfate tablet with a 10 cc placebo syrup thrice daily. Before and after the intervention, key markers like red blood cell count (RBC), mean corpuscular volume (MCV), hemoglobin (Hb), hematocrit (Hct), ferritin, total iron binding capacity (TIBC), and serum iron were assessed. Notably, both Hb and Hct levels were significantly higher in the GS group ( < .05). Additionally, RBC and MCV values showed significant improvement compared to the placebo group ( < .05). However, no significant difference was observed for other iron deficiency markers like serum iron, ferritin, and TIBC ( > .05). This study's findings suggest that combining grape syrup with iron tablets might offer potential advantages over iron tablets alone in managing iron deficiency anemia.
在全球范围内，缺铁是最普遍的营养失调问题，贫血对育龄妇女的影响尤为严重。尽管现有治疗方法（如铁补充剂）有效，但其副作用仍是一个问题。本研究探讨了富含铁的功能性食品葡萄糖浆（GS）调节女性缺铁性贫血标志物的潜力。一项随机双盲研究探讨了GS对130名女性缺铁性贫血标志物的影响。参与者被分配到干预组或安慰剂组。在4周内，干预组每天服用50毫克硫酸亚铁片，同时每天三次服用10毫升GS。安慰剂组每天三次服用50毫克硫酸亚铁片和10毫升安慰剂糖浆。在干预前后，评估了红细胞计数（RBC）、平均红细胞体积（MCV）、血红蛋白（Hb）、血细胞比容（Hct）、铁蛋白、总铁结合力（TIBC）和血清铁等关键标志物。值得注意的是，GS组的Hb和Hct水平均显著更高（<0.05）。此外，与安慰剂组相比，RBC和MCV值有显著改善（<0.05）。然而，在血清铁、铁蛋白和TIBC等其他缺铁标志物方面未观察到显著差异（>0.05）。本研究结果表明，在治疗缺铁性贫血方面，将葡萄糖浆与铁片联合使用可能比单独使用铁片具有潜在优势。
