Zhang Shuyang, Zhao Yuheng, Lalsiamthara Jonathan, Peng Yan, Qi Linlong, Deng Shuli, Wang Qingjing
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China.
Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang, China.
Crit Rev Microbiol. 2024 Aug 14:1-18. doi: 10.1080/1040841X.2024.2390594.
is a Gram-negative anaerobic bacterium that is a common pathogen of periodontitis. Recent studies have revealed that is closely associated with a variety of diseases involving multiple systems. Under the action of its virulence factors such as cysteine protease and adhesins, has the ability to bind and invade various host cells including gingival fibroblasts. It can also copolymerize a variety of pathogenic bacteria, leading to interference with the host's immune inflammatory response and causing various diseases. In this article, we review the progress of research on virulence factors and bacterial pathogenesis, and the correlation between and various diseases.
是一种革兰氏阴性厌氧菌，是牙周炎的常见病原体。最近的研究表明，它与涉及多个系统的多种疾病密切相关。在其半胱氨酸蛋白酶和黏附素等毒力因子的作用下，它有能力结合并侵入包括牙龈成纤维细胞在内的各种宿主细胞。它还能与多种病原菌共聚，导致干扰宿主的免疫炎症反应并引发各种疾病。在本文中，我们综述了关于其毒力因子和细菌发病机制的研究进展，以及它与各种疾病之间的相关性。
