Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang Province, College of Food Science and Engineering, Ningbo University, Ningbo 315800, China.
School of Agriculture and Food, Faculty of Science, University of Melbourne, 3010, Australia.
Food Chem. 2024 Dec 1;460(Pt 3):140663. doi: 10.1016/j.foodchem.2024.140663. Epub 2024 Jul 30.
Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder during pregnancy that alters the metabolites in human milk. Integrated Gas Chromatography-Mass Spectrometry (GC-MS) and Liquid Chromatography-Mass Spectrometry (LC-MS) were employed for comprehensive identification and comparison of metabolites in mature human milk (MHM) from women with and without GDM. A total of 268 differentially expressed metabolites (DEMs) were identified. Among these, linoleic acid, arachidonic acid, 9R-HODE and L-glutamic acid were significantly elevated and 12,13-DHOME was significantly decreased in MHM of women with GDM. These metabolites are significantly enriched in linoleic acid metabolism, fatty acid biosynthesis, galactose metabolism and ABC transporters pathways. Disorders in these metabolic pathways are associated with insulin resistance and poor glucose metabolism indicating these conditions may persist postpartum.
妊娠期糖尿病（GDM）是一种常见的妊娠代谢紊乱疾病，可改变人乳中的代谢物。本研究采用气相色谱-质谱联用（GC-MS）和液相色谱-质谱联用（LC-MS）技术对 GDM 患者和健康产妇成熟乳（MHM）中的代谢物进行全面鉴定和比较。共鉴定出 268 个差异表达代谢物（DEMs）。其中，GDM 患者 MHM 中的亚油酸、花生四烯酸、9R-HODE 和 L-谷氨酸明显升高，12,13-DHOME 明显降低。这些代谢物在亚油酸代谢、脂肪酸生物合成、半乳糖代谢和 ABC 转运体途径中显著富集。这些代谢途径的紊乱与胰岛素抵抗和葡萄糖代谢不良有关，表明这些情况可能在产后持续存在。
