National Institute of Clinical Research, Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
Department of Pharmacy, Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
Cancer Epidemiol. 2024 Oct;92:102647. doi: 10.1016/j.canep.2024.102647. Epub 2024 Aug 13.
Height is associated with increased cancer risk, but most studies focus on Western populations. We aimed to evaluate this relationship in East Asians.
Observational analyses were performed utilizing data from China Kadoorie Biobank (CKB) prospective cohort. Adjusted hazard ratios (HRs) and corresponding 95 % confidence intervals (CIs) were estimated using Cox proportional hazards models. Two-sample Mendelian randomization (MR) analyses explored causal effects between height and cancer using data from Korean Genome and Epidemiology Study (KoGES), Biobank Japan (BBJ), and CKB.
Over a median 10.1-years follow-up, 22,731 incident cancers occurred. In observational analyses, after Bonferroni correction, each 10 cm increase in height was significantly associated with higher risk of overall cancer (HR 1.16, 95 % CI 1.14-1.19, P < 0.001), lung cancer (1.18, 95 % CI 1.12-1.24, P < 0.001), esophageal cancer (1.21, 95 % CI 1.12-1.30, P < 0.001), breast cancer (1.41, 95 % CI 1.31-1.53, P < 0.001), and cervix uteri cancer (1.29, 95 % CI 1.15-1.45, P < 0.001). Each 10 cm increase in height was suggestively associated with increased risk for lymphoma (1.18, 95 % CI 1.04-1.34, P = 0.010), colorectal cancer (1.09, 95 % CI 1.02-1.16, P = 0.010), and stomach cancer (1.07, 95 % CI 1.00-1.14, P = 0.044). In MR analyses, genetically predicted height (per 1 standard deviation increase, 8.07 cm) was suggestively associated with higher risk of lung cancer (odds ratio [OR] 1.17, 95 % confidence interval [CI] 1.02-1.35, P = 0.0244) and gastric cancer (OR 1.14, 95 % CI 1.02-1.29, P = 0.0233).
Taller height was significantly related to a higher risk for overall cancer, lung cancer, esophageal cancer, breast cancer, and cervix uteri cancer. Our findings suggest that height may be a potential causal risk factor for lung and gastric cancers among East Asians.
身高与癌症风险增加有关，但大多数研究都集中在西方人群。我们旨在评估东亚人群中的这种关系。
利用中国慢性病前瞻性研究（CKB）的前瞻性队列数据进行观察性分析。使用 Cox 比例风险模型估计调整后的风险比（HR）和相应的 95%置信区间（CI）。使用来自韩国基因组与流行病学研究（KoGES）、日本生物银行（BBJ）和 CKB 的孟德尔随机化（MR）分析，探讨身高与癌症之间的因果关系。
在中位 10.1 年的随访期间，发生了 22731 例癌症事件。在观察性分析中，经过 Bonferroni 校正后，身高每增加 10cm，总体癌症（HR 1.16，95%CI 1.14-1.19，P < 0.001）、肺癌（HR 1.18，95%CI 1.12-1.24，P < 0.001）、食管癌（HR 1.21，95%CI 1.12-1.30，P < 0.001）、乳腺癌（HR 1.41，95%CI 1.31-1.53，P < 0.001）和宫颈癌（HR 1.29，95%CI 1.15-1.45，P < 0.001）的风险显著增加。身高每增加 10cm，淋巴瘤（HR 1.18，95%CI 1.04-1.34，P = 0.010）、结直肠癌（HR 1.09，95%CI 1.02-1.16，P = 0.010）和胃癌（HR 1.07，95%CI 1.00-1.14，P = 0.044）的风险也有升高的趋势。在 MR 分析中，身高（每增加 1 个标准差，8.07cm）与肺癌（OR 1.17，95%CI 1.02-1.35，P = 0.0244）和胃癌（OR 1.14，95%CI 1.02-1.29，P = 0.0233）风险增加显著相关。
较高的身高与总体癌症、肺癌、食管癌、乳腺癌和宫颈癌的风险增加显著相关。我们的研究结果表明，身高可能是东亚人群中肺癌和胃癌的潜在因果风险因素。
