Lupan Iulia, Silaghi Ciprian, Stroe Claudia, Muntean Adriana, Deleanu Diana, Bintintan Vasile, Samasca Gabriel
Department of Molecular Biology, Babes-Bolyai University, 400084 Cluj-Napoca, Romania.
Department of Biochemistry, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Biomedicines. 2024 Nov 21;12(12):2655. doi: 10.3390/biomedicines12122655.
Gastrointestinal cancers (GIC), encompassing colonic, rectal, and gastric malignancies, rank among the most prevalent cancer types globally, contributing significantly to cancer-related mortality. In the scientific literature, various syndromes associated with colorectal and gastric cancers have been elucidated, highlighting the intricate interplay between genetic factors and disease manifestation. The primary objective of this study was to conduct a genetic exploration aimed at elucidating these associations and identifying shared genetic determinants across these cancer types. Notably, considerable research has focused on the KRAS gene mutations, polymorphisms in nucleic acids, the Wnt signaling pathway, and the role of chemokine ligands in tumorigenesis. While investigations into natural plant extracts as potential therapeutic agents are still in their nascent stages, they represent a promising avenue for future research. Ongoing studies are essential to uncover suitable biomarkers that could facilitate the identification and understanding of the genetic links between these GIC. This exploration not only seeks to enhance our comprehension of the underlying genetic architecture but also aims to inform the development of targeted therapies and preventive strategies.
胃肠道癌症（GIC），包括结肠癌、直肠癌和胃癌，是全球最常见的癌症类型之一，在癌症相关死亡率中占很大比例。在科学文献中，已经阐明了与结直肠癌和胃癌相关的各种综合征，突出了遗传因素与疾病表现之间的复杂相互作用。本研究的主要目的是进行一项基因探索，旨在阐明这些关联，并识别这些癌症类型之间共享的遗传决定因素。值得注意的是，大量研究集中在KRAS基因突变、核酸多态性、Wnt信号通路以及趋化因子配体在肿瘤发生中的作用。虽然将天然植物提取物作为潜在治疗剂的研究仍处于初期阶段，但它们代表了未来研究的一个有前景的途径。进行中的研究对于发现合适的生物标志物至关重要，这些生物标志物有助于识别和理解这些胃肠道癌症之间的遗传联系。这种探索不仅旨在增强我们对潜在遗传结构的理解，还旨在为靶向治疗和预防策略的开发提供信息。
