ZFP318 为记忆 B 细胞的成功提供燃料。
ZFP318 fuels memory B cells for success.
机构信息
Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Immunology Program, Babraham Institute, Cambridge, UK.
出版信息
Immunity. 2024 Aug 13;57(8):1723-1725. doi: 10.1016/j.immuni.2024.07.017.
PMID:39142271
Abstract
Diversity is a key feature of B cell biology-from BCR rearrangement to the heterogeneity of memory B cells. In this issue of Immunity, Wang et al. show that the zinc-finger protein ZFP318 supports mitochondrial health in certain memory B cells, thereby facilitating potent recall upon rechallenge.
摘要
多样性是 B 细胞生物学的一个关键特征——从 BCR 重排到记忆 B 细胞的异质性。在本期《免疫》杂志上，Wang 等人表明锌指蛋白 ZFP318 支持某些记忆 B 细胞中的线粒体健康，从而在再次受到挑战时促进有效的回忆反应。
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