非甾体抗炎药对人多形核细胞和淋巴细胞迁移的体外作用。
In vitro effects of non-steroidal anti-inflammatory drugs on human polymorphonuclear cells and lymphocyte migration.
作者信息
Brown K A, Collins A J
出版信息
Br J Pharmacol. 1978 Nov;64(3):347-52.
Abstract
- The action of the non-steroidal anti-inflammatory drugs (NSAID), sodium salicylate, aspirin, phenylbutazone and indomethacin was investigated on the migration of human polymorphonuclear cells (PMNs) and lymphocytes, using the system of migration of leucocytes from glass capillary tubes. 2. All NSAID produced a dose-dependent inhibition of cell migration, and were more effective on the migration of the PMN than on lymphocytes. 3. Drugs optimally suppressed PMN migration after 20 to 24 h incubation, and lymphocytes after 3 to 6 h. 4. Prolonged incubation of cells with several concentrations of NSAID demonstrated an 'escape' from inhibition in PMNs prepared from one subject.
摘要
- 使用白细胞从玻璃毛细管迁移的系统，研究了非甾体抗炎药（NSAID）、水杨酸钠、阿司匹林、保泰松和吲哚美辛对人多形核细胞（PMN）和淋巴细胞迁移的作用。2. 所有NSAID均产生剂量依赖性的细胞迁移抑制作用，且对PMN迁移的抑制作用比对淋巴细胞更有效。3. 药物在孵育20至24小时后能最佳地抑制PMN迁移，在孵育3至6小时后能最佳地抑制淋巴细胞迁移。4. 用几种浓度的NSAID对细胞进行长时间孵育，结果显示来自一名受试者的PMN出现了抑制“逃逸”现象。
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