中国口腔癌的死亡率和疾病负担：基于 2006 至 2021 年中国死因监测数据库的时间趋势分析。
Mortality and disease burden of oral cancer in China: a time-trend analysis on the China Death Surveillance Database from 2006 to 2021.
机构信息
Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan Province, China.
Henan Key Laboratory of Tumor Epidemiology and State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, 450052, Henan Province, China.
出版信息
BMC Oral Health. 2024 Aug 14;24(1):938. doi: 10.1186/s12903-024-04717-5.
BACKGROUND
Oral cancer is one of the most common cancers in China and seriously threaten life and health of Chinese people. We analysed the trends and disparities of oral cancer mortality rates and the disease burden of oral cancer in China from 2006 to 2021 to provide a reference for its prevention and control.
METHODS
Annual death data for oral cancer was gleaned from the China Death Surveillance Database. The age-standardized mortality rate (ASMR), annual percentage change (APC), and average APC (AAPC) were used to analyze the trend of mortality. Loss of life expectancy (LLE) and years of life lost (YLL) were adopted to assess disease burden.
RESULTS
From 2006 to 2021, the overall ASMR of oral cancer lightly declined (AAPC: - 0.97%; 95% CI: - 1.89%, - 0.04%), and the similar trend was observed among females (AAPC: - 1.22%; 95% CI: - 1.89%, - 0.55%). The ASMR of males was 2.31-3.16 times higher than that of females per year. The median of LLE for overall, males and females caused by oral cancer from 2006 to 2021 were 0.05, 0.06 and 0.03 years, respectively. There was a decrease of standardized YLL rate from 2006 to 2021 for overall (AAPC: - 1.31%, 95% CI: - 2.24% ~ - 0.37%) and for female (AAPC: - 1.63%, 95% CI: - 2.30% ~ - 0.95%). ASMR in urban areas was 1.02-1.28 times higher than that in rural areas from 2006 to2011, but 0.85-0.97 times lower in urban areas than that in rural areas from 2018 to 2021. The disease burden was higher in urban areas than in rural areas in 2006, whereas the reverse was observed in 2021.
CONCLUSIONS
There are severe health gaps and disparities in trends between sexes and different areas in China. Males and rural populations need to be focused on targeted interventions for the main influencing factors.
背景
口腔癌是中国最常见的癌症之一，严重威胁着中国人民的生命和健康。我们分析了 2006 年至 2021 年中国口腔癌死亡率的趋势和差异以及口腔癌疾病负担，为其防治提供参考。
方法
从中国死因监测数据库中收集了口腔癌的年度死亡数据。使用年龄标准化死亡率（ASMR）、年变化百分比（APC）和平均 APC（AAPC）来分析死亡率趋势。采用预期寿命损失（LLE）和寿命损失年（YLL）来评估疾病负担。
结果
2006 年至 2021 年期间，总体口腔癌 ASMR 略有下降（AAPC：-0.97%；95%CI：-1.89%，-0.04%），女性也呈现出类似的趋势（AAPC：-1.22%；95%CI：-1.89%，-0.55%）。男性每年的 ASMR 是女性的 2.31-3.16 倍。2006 年至 2021 年期间，总体、男性和女性因口腔癌导致的 LLE 中位数分别为 0.05、0.06 和 0.03 年。2006 年至 2021 年期间，总体和女性标准化 YLL 率呈下降趋势（AAPC：-1.31%，95%CI：-2.24%-0.37%和 AAPC：-1.63%，95%CI：-2.30%-0.95%）。2006 年至 2011 年期间，城市地区的 ASMR 是农村地区的 1.02-1.28 倍，但 2018 年至 2021 年期间，城市地区的 ASMR 是农村地区的 0.85-0.97 倍。2006 年，城市地区的疾病负担高于农村地区，而 2021 年则相反。
结论
中国男女之间以及不同地区之间的健康差距和趋势存在严重差异。男性和农村人口需要针对主要影响因素进行有针对性的干预。
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