2006年至2017年中国主要肝脏疾病死亡率趋势及其对预期寿命的影响

Trend of the mortality of major liver diseases and its impact on life expectancy in China from 2006 to 2017.

作者信息

Zhu Jicun, Wang Peng, Ye Hua, Shi Jianxiang, Wang Xiao, Wang Keyan, Duan Fujiao, Yang Qian, Sun Guiying, Zhang Jianying

机构信息

Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.

Henan Key Laboratory of Tumor Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.

出版信息

J Public Health (Oxf). 2022 Mar 7;44(1):100-110. doi: 10.1093/pubmed/fdaa261.

DOI:10.1093/pubmed/fdaa261

PMID:33454770

Abstract

BACKGROUND

Liver diseases are the serious cause of death in China. We aim to describe the trends and disparities of major liver disease mortality rates and the loss of life expectancy (LLE) in China.

METHODS

Annual percentage change (APC) and average APC (AAPC) were calculated using the Joinpoint regression model. LLE was calculated using cause eliminated life table.

RESULTS

From 2006 to 2017, the overall age-standardized mortality rate (ASMR) of liver cirrhosis lightly declined (AAPC: -2.97%), whereas the ASMR of viral hepatitis and liver cancer remained stable. Viral hepatitis (AAPC: -4.36%) and liver cirrhosis (AAPC: -4.35%) ASMRs both declined for females. The highest ASMRs of viral hepatitis and liver cirrhosis were in the west region, while that of liver cancer was in the middle region. The ASMRs of liver cirrhosis in the middle region and liver cancer in the east region significantly decreased. The means of LLE on viral hepatitis, liver cirrhosis and liver cancer were 0.05, 0.1 and 0.46 years, respectively.

CONCLUSIONS

The burden of liver diseases is still severe and there are disparities between genders and different regions in China. Accurate early diagnostic approaches for high-risk populations should be established to eliminate the burden of liver diseases.

摘要

背景

肝脏疾病是中国严重的死亡原因。我们旨在描述中国主要肝脏疾病死亡率和预期寿命损失（LLE）的趋势及差异。

方法

使用Joinpoint回归模型计算年度百分比变化（APC）和平均APC（AAPC）。使用去除病因寿命表计算LLE。

结果

2006年至2017年，肝硬化的总体年龄标准化死亡率（ASMR）略有下降（AAPC：-2.97%），而病毒性肝炎和肝癌的ASMR保持稳定。女性的病毒性肝炎（AAPC：-4.36%）和肝硬化（AAPC：-4.35%）的ASMR均下降。病毒性肝炎和肝硬化的ASMR最高的是西部地区，而肝癌的ASMR最高的是中部地区。中部地区的肝硬化ASMR和东部地区的肝癌ASMR显著下降。病毒性肝炎、肝硬化和肝癌的LLE均值分别为0.05、0.1和0.46年。