Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Zhengzhou University, 2 Jingba Road, Zhengzhou, 450001, Henan, People's Republic of China.
College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
BMC Womens Health. 2022 Dec 7;22(1):504. doi: 10.1186/s12905-022-02104-2.
Malignant tumors of reproductive system seriously threaten women's life and health. We analyzed the changes in mortality and disease burden of cervical cancer, uterine cancer and ovarian cancer in China from 2006 to 2020 to provide a basis for formulating scientific prevention and control measures.
Annual death data for cervical cancer, uterine cancer and ovarian cancer were collected from the Chinese Cause of Death Surveillance. The crude mortality rate (CMR), age-standardized mortality rate (ASMR), annual percentage change (APC), and average APC (AAPC) were applied to analyze the trend of mortality. Loss of life expectancy (LLE) and years of life lost (YLL) were used to assess disease burden.
From 2006 to 2020, there was no significant change in the total ASMR and standardized YLL rates of malignant tumors of the reproductive system, leading to an average LLE of 0.18 years. The YLL rate was the highest in the 55-59 age group. The mortality rate and disease burden of the three types of cancer have changed from uterine cancer higher than cervical cancer and ovarian cancer in 2006 to cervical cancer higher than ovarian cancer and uterine cancer in 2020. The ASMR and standardized YLL rate of uterine cancer showed a downward trend, and AAPC was - 5.21% (- 9.31% ~ - 0.91%) and - 6.07% (- 9.45% ~ - 2.58%), respectively. The mortality rates of cervical cancer and ovarian cancer remain high.
The mortality and disease burden of malignant tumors of the female reproductive system in China are still at a high level. It is necessary to improve screening and prevention strategies as soon as possible, improve the techniques of diagnosis and treatment, and take adequate measures to protect women's life and health.
生殖系统恶性肿瘤严重威胁着女性的生命健康。本研究分析了 2006 年至 2020 年中国宫颈癌、子宫体癌和卵巢癌的死亡率和疾病负担变化，为制定科学的防治措施提供依据。
收集中国死因监测系统中宫颈癌、子宫体癌和卵巢癌的年度死亡数据，应用粗死亡率（CMR）、年龄标化死亡率（ASMR）、年度变化百分比（APC）和平均年度变化百分比（AAPC）分析死亡率变化趋势，采用期望寿命损失年（LLE）和减寿年数（YLL）评价疾病负担。
2006 年至 2020 年，生殖系统恶性肿瘤的总 ASMR 和标准化 YLL 率没有显著变化，导致平均 LLE 减少 0.18 年。YLL 率在 5559 岁年龄组最高。三种癌症的死亡率和疾病负担已由 2006 年的子宫体癌高于宫颈癌和卵巢癌转变为 2020 年的宫颈癌高于卵巢癌和子宫体癌。子宫体癌的 ASMR 和标准化 YLL 率呈下降趋势，AAPC 分别为-5.21%（-9.31%-0.91%）和-6.07%（-9.45%~-2.58%）。宫颈癌和卵巢癌的死亡率仍居高不下。
中国女性生殖系统恶性肿瘤的死亡率和疾病负担仍处于较高水平，有必要尽快完善筛查和防治策略，提高诊治技术水平，采取综合措施保障女性生命健康。
