Postgraduate Program in Health Sciences, University of Southern Santa Catarina at Tubarão, Santa Catarina, Brazil.
Department of Virology, Adolfo Lutz Institute, São Paulo, Brazil.
Curr HIV Res. 2024;22(4):230-239. doi: 10.2174/011570162X296948240802075249.
Therapeutic measures have been successful in increasing survival rates and quality of life of HIV/AIDS-infected people. However, some people fail to respond to antiretroviral therapy (HAART) because of viral resistance-associated mutations.
To identify virus genotype and the presence of mutations that alter the susceptibility to HAART, and factors associated with the occurrence of these mutations.
A cross-sectional study was conducted on adults living with HIV attending a specialized outpatient clinic in southern Santa Catarina, Brazil. The participants were interviewed and had blood samples collected for analysis. Those with detectable viral load were genotyped.
Out of the 629 patients recruited, 127 subjects were included due to having a detectable viral load. The most common mutations were M184V and K103N. HIV-1 subtype C was the most prevalent strain. Resistance to HAART was associated with modification in the treatment regimen (p <0.001).
This study concluded that the circulating subtype virus was subtype C and that the mutations K103N and M184V were the most prevalent strains in southern Santa Catarina, Brazil.
治疗措施已成功提高了 HIV/AIDS 感染者的生存率和生活质量。然而，由于病毒耐药相关突变，有些人无法对抗逆转录病毒治疗（HAART）产生反应。
鉴定与改变 HAART 敏感性相关的病毒基因型和突变，并确定与这些突变发生相关的因素。
在巴西南圣卡塔琳娜州的一家专门的门诊诊所，对成年 HIV 感染者进行了一项横断面研究。对参与者进行了访谈，并采集了血液样本进行分析。对那些可检测到病毒载量的患者进行了基因分型。
在招募的 629 名患者中，有 127 名患者由于可检测到病毒载量而被纳入研究。最常见的突变是 M184V 和 K103N。HIV-1 亚型 C 是最常见的毒株。对 HAART 的耐药性与治疗方案的改变有关（p<0.001）。
本研究表明，流行的病毒亚型为 C 型，在巴西南圣卡塔琳娜州，K103N 和 M184V 是最常见的突变株。
