• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

衰老导致的血脑屏障功能障碍是由脑内皮细胞衰老引起的。

Blood-brain barrier dysfunction in aging is mediated by brain endothelial senescence.

机构信息

CNC-UC Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.

University of Coimbra, Institute for Interdisciplinary Research, Doctoral Programme in Experimental Biology and Biomedicine (PDBEB), Coimbra, Portugal.

出版信息

Aging Cell. 2024 Sep;23(9):e14270. doi: 10.1111/acel.14270. Epub 2024 Aug 15.

DOI:10.1111/acel.14270
PMID:39143890
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11488312/
Abstract

BBB dysfunction during aging is characterized by an increase in its permeability and phenotypic alterations of brain endothelial cells (BECs) including dysregulation of tight junction's expression. Here we have investigated the role of BEC senescence in the dysfunction of the BBB. Our results suggest that the transition from young to aged BBB is mediated, at least in part by BEC senescence.

摘要

随着年龄的增长，BBB 的功能障碍表现为通透性增加和脑内皮细胞（BEC）表型改变，包括紧密连接表达失调。在此，我们研究了 BEC 衰老在 BBB 功能障碍中的作用。我们的结果表明，从年轻 BBB 向衰老 BBB 的转变至少部分是由 BEC 衰老介导的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/332b/11488312/d3d61a060d82/ACEL-23-e14270-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/332b/11488312/f1531deef5a3/ACEL-23-e14270-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/332b/11488312/d3d61a060d82/ACEL-23-e14270-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/332b/11488312/f1531deef5a3/ACEL-23-e14270-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/332b/11488312/d3d61a060d82/ACEL-23-e14270-g001.jpg

相似文献

1
Blood-brain barrier dysfunction in aging is mediated by brain endothelial senescence.衰老导致的血脑屏障功能障碍是由脑内皮细胞衰老引起的。
Aging Cell. 2024 Sep;23(9):e14270. doi: 10.1111/acel.14270. Epub 2024 Aug 15.
2
Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown.血管细胞衰老导致血脑屏障破坏。
Stroke. 2016 Apr;47(4):1068-77. doi: 10.1161/STROKEAHA.115.010835. Epub 2016 Feb 16.
3
Transcriptional profiling of human brain endothelial cells reveals key properties crucial for predictive in vitro blood-brain barrier models.人类脑内皮细胞的转录组分析揭示了预测性体外血脑屏障模型的关键特性。
PLoS One. 2012;7(5):e38149. doi: 10.1371/journal.pone.0038149. Epub 2012 May 31.
4
The between Endothelial Cilia and Endothelial Nanotubules Is an Evolving Concept in the Genesis of the BBB.内皮纤毛和内皮纳米管之间的关系是 BBB 发生过程中的一个新兴概念。
Int J Mol Sci. 2022 Feb 23;23(5):2457. doi: 10.3390/ijms23052457.
5
Endothelial Cell Senescence Effect on the Blood-Brain Barrier in Stroke and Cognitive Impairment.内皮细胞衰老对卒中及认知障碍血脑屏障的影响。
Neurology. 2024 Dec 10;103(11):e210063. doi: 10.1212/WNL.0000000000210063. Epub 2024 Nov 14.
6
Moderate hypoxia followed by reoxygenation results in blood-brain barrier breakdown via oxidative stress-dependent tight-junction protein disruption.中度缺氧后再复氧会导致血脑屏障破坏，这是通过氧化应激依赖性紧密连接蛋白破坏实现的。
PLoS One. 2013 Dec 6;8(12):e82823. doi: 10.1371/journal.pone.0082823. eCollection 2013.
7
miR-27a-3p regulates expression of intercellular junctions at the brain endothelium and controls the endothelial barrier permeability.miR-27a-3p 调节脑内皮细胞的细胞间连接表达，并控制内皮屏障通透性。
PLoS One. 2022 Jan 13;17(1):e0262152. doi: 10.1371/journal.pone.0262152. eCollection 2022.
8
Acid sphingomyelinase-mediated blood-brain barrier disruption in aging.衰老过程中酸性鞘磷脂酶介导的血脑屏障破坏。
BMB Rep. 2019 Feb;52(2):111-112. doi: 10.5483/BMBRep.2019.52.2.033.
9
Senescence and associated blood-brain barrier alterations in vitro.体外衰老及相关血脑屏障改变
Histochem Cell Biol. 2021 Sep;156(3):283-292. doi: 10.1007/s00418-021-01992-z. Epub 2021 May 27.
10
Brain endothelial GSDMD activation mediates inflammatory BBB breakdown.脑内皮细胞中Gasdermin D（GSDMD）的激活介导了炎症性血脑屏障破坏。
Nature. 2024 May;629(8013):893-900. doi: 10.1038/s41586-024-07314-2. Epub 2024 Apr 17.

引用本文的文献

1
Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments.全身环境对脑血管和脑衰老的影响：来自异时联体共生、血液交换和血浆转移实验的见解
Geroscience. 2025 May 23. doi: 10.1007/s11357-025-01657-y.
2
Spontaneous intracerebral hemorrhage during computed tomography scanning-assessment of hyperacute hematoma growth.计算机断层扫描期间自发性脑出血——超急性血肿生长的评估
Geroscience. 2025 May 10. doi: 10.1007/s11357-025-01696-5.
3
Inflammaging and Brain Aging.

本文引用的文献

1
Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice.全身性衰老细胞清除可减轻小鼠与年龄相关的脑炎症和认知障碍。
Aging Cell. 2021 Feb;20(2):e13296. doi: 10.1111/acel.13296. Epub 2021 Jan 20.
2
Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain.与神经退行性疾病相关的衰老大脑中，具有药物可逆性的区域依赖性内皮细胞转录组变化。
Nat Commun. 2020 Sep 4;11(1):4413. doi: 10.1038/s41467-020-18249-3.
3
Neuronal regulation of the blood-brain barrier and neurovascular coupling.
炎症与大脑衰老。
Int J Mol Sci. 2024 Sep 30;25(19):10535. doi: 10.3390/ijms251910535.
神经元对血脑屏障和神经血管耦联的调节。
Nat Rev Neurosci. 2020 Aug;21(8):416-432. doi: 10.1038/s41583-020-0322-2. Epub 2020 Jul 7.
4
Physiological blood-brain transport is impaired with age by a shift in transcytosis.随着年龄增长，经细胞转运的改变会损害生理性血脑转运。
Nature. 2020 Jul;583(7816):425-430. doi: 10.1038/s41586-020-2453-z. Epub 2020 Jul 1.
5
Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues.脑内皮细胞是与年龄相关的循环线索的敏感传感器。
Cell Rep. 2020 Mar 31;30(13):4418-4432.e4. doi: 10.1016/j.celrep.2020.03.012.
6
Senescence in Post-Mitotic Cells: A Driver of Aging?有丝分裂后细胞衰老：衰老的驱动因素？
Antioxid Redox Signal. 2021 Feb 1;34(4):308-323. doi: 10.1089/ars.2020.8048. Epub 2020 Apr 27.
7
Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction.衰老导致血脑屏障功能障碍，进而引发 TGFβ 信号的过度激活和慢性但可恢复的神经功能障碍。
Sci Transl Med. 2019 Dec 4;11(521). doi: 10.1126/scitranslmed.aaw8283.
8
Cellular Senescence: Defining a Path Forward.细胞衰老：定义前进的道路。
Cell. 2019 Oct 31;179(4):813-827. doi: 10.1016/j.cell.2019.10.005.
9
Single-cell transcriptomic profiling of the aging mouse brain.单细胞转录组谱分析衰老小鼠大脑。
Nat Neurosci. 2019 Oct;22(10):1696-1708. doi: 10.1038/s41593-019-0491-3. Epub 2019 Sep 24.
10
Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction.血脑屏障破坏是人类认知功能障碍的早期生物标志物。
Nat Med. 2019 Feb;25(2):270-276. doi: 10.1038/s41591-018-0297-y. Epub 2019 Jan 14.