Liang Yixia, Wu Guo, Tan Jiabao, Xiao Xiaoyun, Yang Linbin, Saw Phei Er
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, Guangdong, China.
Nanhai Translational Innovation Center of Precision Immunology, Sun Yat-Sen Memorial Hospital, Foshan 528200, Guangdong, China.
Cancer Drug Resist. 2024 Jul 19;7:28. doi: 10.20517/cdr.2024.24. eCollection 2024.
Neutrophils are recognized active participants in inflammatory responses and are intricately linked to cancer progression. In response to inflammatory stimuli, neutrophils become activated, releasing neutrophils extracellular traps (NETs) for the capture and eradication of pathogens, a phenomenon termed NETosis. With a deeper understanding of NETs, there is growing evidence supporting their role in cancer progression and their involvement in conferring resistance to various cancer therapies, especially concerning tumor reactions to chemotherapy, radiation therapy (RT), and immunotherapy. This review summarizes the roles of NETs in the tumor microenvironment (TME) and their mechanisms of neutrophil involvement in the host defense. Additionally, it elucidates the mechanisms through which NETs promote tumor progression and their role in cancer treatment resistance, highlighting their potential as promising therapeutic targets in cancer treatment and their clinical applicability.
中性粒细胞被认为是炎症反应的积极参与者，并且与癌症进展密切相关。在炎症刺激下，中性粒细胞被激活，释放中性粒细胞胞外陷阱（NETs）以捕获和清除病原体，这一现象称为NETosis。随着对NETs的深入了解，越来越多的证据支持它们在癌症进展中的作用以及它们参与赋予对各种癌症治疗的抗性，特别是关于肿瘤对化疗、放射治疗（RT）和免疫治疗的反应。本综述总结了NETs在肿瘤微环境（TME）中的作用以及中性粒细胞参与宿主防御的机制。此外，它阐明了NETs促进肿瘤进展的机制及其在癌症治疗抗性中的作用，突出了它们作为癌症治疗中有望的治疗靶点的潜力及其临床适用性。
