Tanaka Hidekazu, Ono Taiki, Kajima Miki, Manabe Yuki, Fujimoto Koya, Yuasa Yuki, Shiinoki Takehiro, Matsuo Masayuki
Department of Radiation Oncology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
Department of Radiology, Gifu University Graduate School of Medicine, Gifu, Gifu, Japan.
Rep Pract Oncol Radiother. 2024 Jun 6;29(2):228-235. doi: 10.5603/rpor.100168. eCollection 2024.
The monocyte-to-lymphocyte ratio (MLR), a systemic inflammation biomarker, has been shown to predict patient outcomes in several types of cancer. This study aimed to determine the association between MLR and local control (LC) and cause-specific survival (CSS) rates in patients with non-small cell lung cancer (NSCLC) treated with stereotactic body radiation therapy (SBRT).
The median age of the 194 included participants (144 men, 50 women) was 80 (range, 50-96) years. The median follow-up period was 19 (range, 1-108) months. The LC and CSS rates were calculated using the Kaplan-Meier method. Univariate and multivariate Cox proportional hazard regression models were used to estimate the LC and CSS rates.
Local recurrence was observed in 25 patients during the follow-up. Univariate Cox proportional hazards regression analysis revealed that MLR, performance status, and tumor diameter were significant factors for LC. Multivariate analysis showed MLR and tumor diameter as significant factors (p = 0.041 and 0.031, respectively). The 1- and 2-year LC rates for the lower and higher MLR groups were 97.5% and 97.5%, and 89.7% and 81.2%, respectively. During the follow-up period, 14 patients died due to NSCLC. Although MLR tended to predict CSS in univariate analysis (p = 0.086), none of the parameters was significant in predicting CSS. However, MLR as a continuous variable was a significant factor for CSS in the univariate analysis (p = 0.004).
Our data suggest that MLR is correlated with LC and CSS rates in NSCLC patients treated with SBRT.
单核细胞与淋巴细胞比值（MLR）作为一种全身炎症生物标志物，已被证明可预测多种癌症患者的预后。本研究旨在确定接受立体定向体部放射治疗（SBRT）的非小细胞肺癌（NSCLC）患者中MLR与局部控制（LC）及特定病因生存率（CSS）之间的关联。
纳入的194名参与者（144名男性，50名女性）的中位年龄为80岁（范围50 - 96岁）。中位随访期为19个月（范围1 - 108个月）。采用Kaplan-Meier法计算LC和CSS率。使用单因素和多因素Cox比例风险回归模型估计LC和CSS率。
随访期间25例患者出现局部复发。单因素Cox比例风险回归分析显示，MLR、体能状态和肿瘤直径是影响LC的重要因素。多因素分析显示MLR和肿瘤直径是显著因素（分别为p = 0.041和0.031）。MLR较低组和较高组的1年和2年LC率分别为97.5%和97.5%，以及89.7%和81.2%。随访期间，14例患者死于NSCLC。虽然在单因素分析中MLR倾向于预测CSS（p = 0.086），但在预测CSS方面没有参数具有显著性。然而，在单因素分析中，MLR作为连续变量是CSS的显著因素（p = 0.004）。
我们的数据表明，在接受SBRT治疗的NSCLC患者中，MLR与LC和CSS率相关。
