Al Katatbeh Mohammad, Al-Mashakbeh Yazan, Freihat Hadeel, Gharam Hiba, Mohammad Rahmeh, Aldalki Rahma, Eid Sadeen, Sharman Reema, Heissat Nizar, Al-Samarraie Ghusoon, Al-Shaibie Ahmad, Khasawneh Laith
Department of Special Surgery, Faculty of Medicine, Hashemite University, Zarqa, Jordan.
Department of Ear Throat Nose, New Zarqa Governmental Hospital, Zarqa, Jordan.
Clin Exp Vaccine Res. 2024 Jul;13(3):218-224. doi: 10.7774/cevr.2024.13.3.218. Epub 2024 Jul 31.
PURPOSE: Sleeping disorders were reported in many patients who took vaccines during previous pandemics. We aim to investigate the relationship between coronavirus disease 2019 (COVID-19) vaccines and the incidence of narcolepsy symptoms in the Jordanian population. MATERIALS AND METHODS: We used a descriptive, cross-sectional, online self-administered survey conducted between December 2022 and May 2023. The survey targeted males and females above the age of 18 years who took any type of COVID-19 vaccine, had no chronic diseases, and had no sleep disorders prior to taking the vaccine. The survey was distributed via social media platforms. RESULTS: A total of 873 participants were included in this study, consisting of 44.4% males and 55.6% females, with the majority being in the 18-29 age group. Most participants (79.8%) received two vaccine doses, with the Pfizer vaccine being the most common. Nearly half of the participants reported excessive daytime sleepiness. Sleep paralysis and hypnagogic hallucinations were reported by a notable proportion of participants, but no significant differences were found among the vaccine types. Sleep attacks and fragmented nighttime sleep were associated with the number of vaccine doses received, suggesting a possible influence of the dose count on these symptoms. The presence of excessive daytime sleepiness, sudden loss of muscle tone, sleep paralysis, and hypnagogic hallucinations showed no significant association with the number of doses taken. CONCLUSION: We hypothesize a possible link between COVID-19 vaccination and the emergence of narcolepsy symptoms in Jordanian individuals. Additional investigations and continuous monitoring to determine the extent of the risk and uncover potential mechanisms behind this connection should be performed.
目的:在以往大流行期间,许多接种疫苗的患者报告出现睡眠障碍。我们旨在研究2019冠状病毒病(COVID-19)疫苗与约旦人群发作性睡病症状发生率之间的关系。 材料与方法:我们采用了一项描述性、横断面、在线自我管理的调查,于2022年12月至2023年5月进行。该调查针对18岁以上接种过任何类型COVID-19疫苗、无慢性病且在接种疫苗前无睡眠障碍的男性和女性。调查通过社交媒体平台分发。 结果:本研究共纳入873名参与者,其中男性占44.4%,女性占55.6%,大多数在18 - 29岁年龄组。大多数参与者(79.8%)接种了两剂疫苗,其中辉瑞疫苗最为常见。近一半的参与者报告有白天过度嗜睡。相当比例的参与者报告有睡眠瘫痪和入睡前幻觉,但不同疫苗类型之间未发现显著差异。睡眠发作和夜间睡眠碎片化与接种的疫苗剂量数有关,表明剂量数可能对这些症状有影响。白天过度嗜睡、突然肌肉张力丧失、睡眠瘫痪和入睡前幻觉的出现与接种剂量数无显著关联。 结论:我们推测在约旦个体中,COVID-19疫苗接种与发作性睡病症状的出现之间可能存在联系。应进行进一步调查和持续监测,以确定风险程度并揭示这种关联背后的潜在机制。
Clin Exp Vaccine Res. 2024-7
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