文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

接种新冠疫苗后发作性睡病症状的发生率:一项约旦横断面研究。

Incidence of narcolepsy symptoms after taking COVID-19 vaccines: a Jordanian cross-sectional study.

作者信息

Al Katatbeh Mohammad, Al-Mashakbeh Yazan, Freihat Hadeel, Gharam Hiba, Mohammad Rahmeh, Aldalki Rahma, Eid Sadeen, Sharman Reema, Heissat Nizar, Al-Samarraie Ghusoon, Al-Shaibie Ahmad, Khasawneh Laith

机构信息

Department of Special Surgery, Faculty of Medicine, Hashemite University, Zarqa, Jordan.

Department of Ear Throat Nose, New Zarqa Governmental Hospital, Zarqa, Jordan.

出版信息

Clin Exp Vaccine Res. 2024 Jul;13(3):218-224. doi: 10.7774/cevr.2024.13.3.218. Epub 2024 Jul 31.


DOI:10.7774/cevr.2024.13.3.218
PMID:39144130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11319113/
Abstract

PURPOSE: Sleeping disorders were reported in many patients who took vaccines during previous pandemics. We aim to investigate the relationship between coronavirus disease 2019 (COVID-19) vaccines and the incidence of narcolepsy symptoms in the Jordanian population. MATERIALS AND METHODS: We used a descriptive, cross-sectional, online self-administered survey conducted between December 2022 and May 2023. The survey targeted males and females above the age of 18 years who took any type of COVID-19 vaccine, had no chronic diseases, and had no sleep disorders prior to taking the vaccine. The survey was distributed via social media platforms. RESULTS: A total of 873 participants were included in this study, consisting of 44.4% males and 55.6% females, with the majority being in the 18-29 age group. Most participants (79.8%) received two vaccine doses, with the Pfizer vaccine being the most common. Nearly half of the participants reported excessive daytime sleepiness. Sleep paralysis and hypnagogic hallucinations were reported by a notable proportion of participants, but no significant differences were found among the vaccine types. Sleep attacks and fragmented nighttime sleep were associated with the number of vaccine doses received, suggesting a possible influence of the dose count on these symptoms. The presence of excessive daytime sleepiness, sudden loss of muscle tone, sleep paralysis, and hypnagogic hallucinations showed no significant association with the number of doses taken. CONCLUSION: We hypothesize a possible link between COVID-19 vaccination and the emergence of narcolepsy symptoms in Jordanian individuals. Additional investigations and continuous monitoring to determine the extent of the risk and uncover potential mechanisms behind this connection should be performed.

摘要

目的:在以往大流行期间,许多接种疫苗的患者报告出现睡眠障碍。我们旨在研究2019冠状病毒病(COVID-19)疫苗与约旦人群发作性睡病症状发生率之间的关系。 材料与方法:我们采用了一项描述性、横断面、在线自我管理的调查,于2022年12月至2023年5月进行。该调查针对18岁以上接种过任何类型COVID-19疫苗、无慢性病且在接种疫苗前无睡眠障碍的男性和女性。调查通过社交媒体平台分发。 结果:本研究共纳入873名参与者,其中男性占44.4%,女性占55.6%,大多数在18 - 29岁年龄组。大多数参与者(79.8%)接种了两剂疫苗,其中辉瑞疫苗最为常见。近一半的参与者报告有白天过度嗜睡。相当比例的参与者报告有睡眠瘫痪和入睡前幻觉,但不同疫苗类型之间未发现显著差异。睡眠发作和夜间睡眠碎片化与接种的疫苗剂量数有关,表明剂量数可能对这些症状有影响。白天过度嗜睡、突然肌肉张力丧失、睡眠瘫痪和入睡前幻觉的出现与接种剂量数无显著关联。 结论:我们推测在约旦个体中,COVID-19疫苗接种与发作性睡病症状的出现之间可能存在联系。应进行进一步调查和持续监测,以确定风险程度并揭示这种关联背后的潜在机制。

相似文献

[1]
Incidence of narcolepsy symptoms after taking COVID-19 vaccines: a Jordanian cross-sectional study.

Clin Exp Vaccine Res. 2024-7

[2]
Hypnagogic and hypnopompic hallucinations: pathological phenomena?

Br J Psychiatry. 1996-10

[3]
The psychosocial problems of children with narcolepsy and those with excessive daytime sleepiness of uncertain origin.

Pediatrics. 2006-10

[4]
Frequencies and Associations of Narcolepsy-Related Symptoms: A Cross-Sectional Study.

J Clin Sleep Med. 2015-12-15

[5]
Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy.

Proc Natl Acad Sci U S A. 2018-5-21

[6]
Side Effects Associated With Homologous and Heterologous COVID-19 Vaccines: A Cross-Sectional Study in Saudi Arabia.

Cureus. 2023-1-21

[7]
Narcolepsy: clinical approach to etiology, diagnosis, and treatment.

Rev Neurol Dis. 2011

[8]
The effects of the COVID-19 pandemic on patients with narcolepsy.

J Clin Sleep Med. 2021-4-1

[9]
Familial narcolepsy.

Neurol Neurochir Pol. 2007

[10]
The Side Effects of COVID-19 Vaccines and Its Association With ABO Blood Type Among the General Surgeons in Saudi Arabia.

Cureus. 2022-3-29

本文引用的文献

[1]
Safety and immunogenicity of anti-SARS-CoV-2 heterologous scheme with SOBERANA 02 and SOBERANA Plus vaccines: Phase IIb clinical trial in adults.

Med. 2022-11-11

[2]
Reactogenic sleepiness after COVID-19 vaccination. A hypothesis involving orexinergic system linked to inflammatory signals.

Sleep Med. 2022-10

[3]
Short-term side effects of COVID-19 vaccines: A cross-sectional study in Jordan.

Hum Vaccin Immunother. 2022-11-30

[4]
Global impact of the first year of COVID-19 vaccination: a mathematical modelling study.

Lancet Infect Dis. 2022-9

[5]
Safety, tolerability, and immunogenicity of a SARS-CoV-2 recombinant spike RBD protein vaccine: A randomised, double-blind, placebo-controlled, phase 1-2 clinical trial (ABDALA Study).

EClinicalMedicine. 2022-4

[6]
Side effects of COVID-19 vaccines: a systematic review and meta-analysis protocol of randomised trials.

BMJ Open. 2022-2-24

[7]
Association between reactogenicity and SARS-CoV-2 antibodies after the second dose of the BNT162b2 COVID-19 vaccine.

Vaccine. 2022-3-18

[8]
Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial.

Lancet. 2021-7-10

[9]
Minor to Moderate Side Effects of Pfizer-BioNTech COVID-19 Vaccine Among Saudi Residents: A Retrospective Cross-Sectional Study.

Int J Gen Med. 2021-4-19

[10]
The Legacy of Sickness Behaviors.

Front Psychiatry. 2020-12-3

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索