Kelley Keith W, Kent Stephen
Department of Pathology, College of Medicine, Urbana, IL, United States.
Department of Animal Sciences, College of Agricultural, Consumer & Environmental Sciences (ACES), University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Front Psychiatry. 2020 Dec 3;11:607269. doi: 10.3389/fpsyt.2020.607269. eCollection 2020.
Systemic infections of all types lead to a syndrome known as sickness behaviors. Changes in the behavior of febrile humans and animals formed the original basis for this concept. Body temperature is behaviorally regulated in both endotherms and ectotherms. However, infections cause other changes in body functions, including sleep disruption, anorexia, cognitive and memory deficits and disorientation. The brain mediates this entire cluster of symptoms, even though most major infections occur outside the brain. The true importance of sickness behaviors is not the numerous discoveries of symptoms that affect all of us when we get sick. Instead, the legacy of 30 years of research in sickness behaviors is that it established the physiologic importance of reciprocal communication systems between the immune system and the brain. This conceptual advance remains in its infancy.
所有类型的全身感染都会导致一种被称为疾病行为的综合征。发热的人类和动物行为的变化构成了这一概念的最初基础。体温在恒温动物和变温动物中都受到行为调节。然而，感染会导致身体功能的其他变化，包括睡眠中断、厌食、认知和记忆缺陷以及定向障碍。大脑介导了这一系列症状，尽管大多数主要感染发生在大脑之外。疾病行为的真正重要性不在于我们生病时影响所有人的众多症状发现。相反，30年疾病行为研究的遗产在于它确立了免疫系统与大脑之间相互通信系统的生理重要性。这一概念上的进展仍处于起步阶段。
