El-Shitany Nagla A, Harakeh Steve, Badr-Eldin Shaimaa M, Bagher Amina M, Eid Basma, Almukadi Haifa, Alghamdi Badrah S, Alahmadi Ahlam A, Hassan Nibal A, Sindi Nariman, Alghamdi Samar A, Almohaimeed Hailah M, Mohammedsaleh Zuhair M, Al-Shaikh Turki M, Almuhayawi Mohammed S, Ali Soad S, El-Hamamsy Manal
Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Int J Gen Med. 2021 Apr 19;14:1389-1401. doi: 10.2147/IJGM.S310497. eCollection 2021.
The Pfizer-BioNTech COVID-19 vaccine has recently received emergency approval from the US FDA. The mRNA technology was used to manufacture the Pfizer vaccine; however, as a pioneering technology that has never been used in the manufacture of vaccines, many people have concerns about the vaccine's side effects. Thus, the current study aimed to track the short-term side effects of the vaccine.
The information in this study was gathered by a Google Form-questionnaire (online survey). The results included the responses of 455 individuals, all of whom are Saudi Arabia inhabitants. Adverse effects of the vaccine were reported after the first and the second doses.
The most common symptoms were injection site pain, headaches, flu-like symptoms, fever, and tiredness. Less common side effects were a fast heartbeat, whole body aches, difficulty breathing, joint pain, chills, and drowsiness. Rare side effects include Bell's palsy and lymph nodes swelling and tenderness. Flu-like symptoms were more common among those under 60 years of age, while injection site pain was more frequent among recipients who were 60 years and older. The study revealed a significant increase in the number of females who suffered from the vaccine side effects compared to males. Difficulty of breathing was more reported among recipients who had been previously infected with the coronavirus compared to those who had not been previously infected.
Most of the side effects reported in this study were consistent with Pfizer's fact sheet for recipients and caregivers. Further studies are required to determine the long-term side effects.
辉瑞 - 生物科技公司的新冠疫苗最近获得了美国食品药品监督管理局的紧急批准。辉瑞疫苗采用mRNA技术制造；然而，作为一种从未用于疫苗制造的开创性技术，许多人对该疫苗的副作用表示担忧。因此，本研究旨在追踪该疫苗的短期副作用。
本研究的信息通过谷歌表单问卷（在线调查）收集。结果包括455名个体的回复，他们均为沙特阿拉伯居民。在接种第一剂和第二剂疫苗后报告了疫苗的不良反应。
最常见的症状是注射部位疼痛、头痛、流感样症状、发热和疲劳。较不常见的副作用有心跳加快、全身疼痛、呼吸困难、关节疼痛、寒战和嗜睡。罕见的副作用包括贝尔氏麻痹以及淋巴结肿大和压痛。流感样症状在60岁以下人群中更为常见，而注射部位疼痛在60岁及以上的接种者中更为频繁。研究显示，与男性相比，出现疫苗副作用的女性人数显著增加。与未感染过冠状病毒的接种者相比，曾感染过冠状病毒的接种者报告呼吸困难的情况更多。
本研究报告的大多数副作用与辉瑞提供给接种者和护理人员的情况说明书一致。需要进一步研究以确定长期副作用。
