Annadurai Thirumagalanuraaga, Vundela Rajashekar R, Chowdhary Nagalakshmi, Shivanna Veena, Rajasekaran Subhathira, Karuppaiah Mahesh Kumar
Department of Pedodontics and Preventive Dentistry, Sri Venkateshwaraa Dental College, Ariyur, Puducherry, India.
Department of Pedodontics and Preventive Dentistry, Sri Siddhartha Dental College and Hospital, Sri Siddhartha Academy of Higher Education, Tumakuru, Karnataka, India.
Int J Clin Pediatr Dent. 2024 Apr;17(4):425-432. doi: 10.5005/jp-journals-10005-2817.
Despite the introduction of several anticaries products, dental caries continues to be a global problem. In recent years, there has been a rise in interest in noninvasive treatment for noncavitated caries lesions by employing remineralization concepts. Each remineralizing agent has its own drawbacks. Therefore, it is desirable to seek new agents that offer the advantages of earlier counterparts with lower detrimental reactions.
The purpose of this research is to evaluate the remineralization efficacy of nanoparticle-based materials on white spot lesion (WSL) in children.
A total of 45 children between the age-group of 4 and 8 years with WSLs were selected and randomly divided into three groups. At baseline, the teeth with WSLs were confirmed and identified using International Caries Detection and Assessment System II (ICDAS II) criteria, and the dimensions of the lesions were measured using photographic methods. Then, they were randomly placed into three groups of 15 samples each-group I nanosilver fluoride (NSF), group II nanohydroxyapatite (nano-HAP) serum, and group III MI varnish. Following that, the varnish was applied, and follow-up was done in the 2nd, 4th, 12th, and 24th week.
By the 4th week, all three groups had a statistically significant difference ( < 0.05). Baseline measurements for groups I, II, and III showed that their respective mean WSL dimensions were 4.9 ± 0.66, 4.27 ± 0.69, and 5.44 ± 2.95. The dimensions of each group were reduced by the 24th week to 1.22 ± 0.46, 0.93 ± 0.41, and 2.19 ± 1.40, respectively. Overall, group II (nano-HAP serum) showed a statistically significant decrease in the dimension of the lesion at the end of the 24th week, followed by groups I and III.
The remineralization of enamel was induced by all three agents. Nano-HAP serum is more successful than MI Varnish and NSF.
Annadurai T, Vundela RR, Chowdhary N, Evaluation of Remineralization Efficacy of Nanoparticle-based Materials on White Spot Lesions in Children: A Comparative Clinical Study. Int J Clin Pediatr Dent 2024;17(4):425-432.
尽管已推出多种防龋产品，但龋齿仍是一个全球性问题。近年来，采用再矿化概念对非龋洞性龋损进行非侵入性治疗的兴趣有所增加。每种再矿化剂都有其自身的缺点。因此，需要寻找新的试剂，它们具有早期同类产品的优点，同时不良反应较少。
本研究的目的是评估纳米颗粒基材料对儿童白斑病变（WSL）的再矿化效果。
选取45名4至8岁患有WSL的儿童，随机分为三组。基线时，使用国际龋病检测与评估系统II（ICDAS II）标准确认并识别有WSL的牙齿，并采用摄影方法测量病变尺寸。然后，将他们随机分为三组，每组15个样本——第一组为纳米银氟化物（NSF），第二组为纳米羟基磷灰石（nano-HAP）血清，第三组为MI涂漆。之后，涂抹涂漆，并在第2、4、12和24周进行随访。
到第4周时，三组均有统计学显著差异（<0.05）。第一组、第二组和第三组的基线测量显示，其各自的平均WSL尺寸分别为4.9±0.66、4.2±0.69和5.44±2.95。到第24周时，每组的尺寸分别降至1.22±0.46、0.93±0.41和2.19±1.40。总体而言，第二组（纳米HAP血清）在第24周结束时病变尺寸有统计学显著下降，其次是第一组和第三组。
所有三种试剂均能诱导牙釉质再矿化。纳米HAP血清比MI涂漆和NSF更成功。
Annadurai T, Vundela RR, Chowdhary N, 评估纳米颗粒基材料对儿童白斑病变的再矿化效果：一项比较临床研究。《国际临床儿科牙科学杂志》2024；17(4):425 - 432。
