猴痘病毒与宿主的相互作用。
The monkeypox virus-host interplays.
作者信息
Yi Xue-Mei, Lei Ya-Li, Li Mi, Zhong Li, Li Shu
机构信息
Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Research Unit of Innate Immune and Inflammatory Diseases (2019RU063), Chinese Academy of Medical Sciences, Wuhan University, Wuhan, 430071, China.
Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
出版信息
Cell Insight. 2024 Jul 14;3(5):100185. doi: 10.1016/j.cellin.2024.100185. eCollection 2024 Oct.
Monkeypox virus (MPXV) is a DNA virus belonging to the genus within the Poxviridae family which can cause a zoonotic infection. The unexpected non-endemic outbreak of mpox in 2022 is considered as a new global threat. It is imperative to take proactive measures, including enhancing our understanding of MPXV's biology and pathogenesis, and developing novel antiviral strategies. The host immune responses play critical roles in defensing against MPXV infection while the virus has also evolved multiple strategies for immune escape. This review summarizes the biological features, antiviral immunity, immune evasion mechanisms, pathogenicity, and prevention strategies for MPXV.
猴痘病毒（MPXV）是一种双链DNA病毒，属于痘病毒科的一个属，可引起人畜共患感染。2022年猴痘意外的非地方性暴发被视为一种新的全球威胁。必须采取积极措施，包括加强我们对猴痘病毒生物学和发病机制的了解，以及开发新的抗病毒策略。宿主免疫反应在抵御猴痘病毒感染中起关键作用，而该病毒也进化出多种免疫逃逸策略。本综述总结了猴痘病毒的生物学特征、抗病毒免疫、免疫逃逸机制、致病性和预防策略。
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